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鱼精蛋白对PLA微球佐剂的调控
刘玉莹; 陈小明; 王连艳; 袁其朋; 马光辉
2013
Source Publication过程工程学报
Issue04Pages:646-653
Abstract采用快速膜乳化法,以聚乳酸(PLA)为材料,分别以乙酸乙酯和二氯甲烷为有机溶剂,制备了粒径400和900nm的均一PLA微球和鱼精蛋白(PS)修饰的PLA-PS微球,以微球为佐剂、HBsAg为抗原免疫小鼠,在动物水平上研究其免疫调控作用,考察了不同粒径微球对抗原体内免疫效果的影响.结果表明,鱼精蛋白修饰后的PLA微球对乙肝表面抗原的吸附率增加,未修饰的PLA微球对抗原的吸附率仅为2.07%,修饰后吸附率为8.16%;修饰后微球为佐剂的免疫效果优于未修饰微球为佐剂的免疫效果,鱼精蛋白修饰能显著提升小鼠脾细胞分泌Th1型细胞因子(IL-2和IFN-γ)数(分别提升了261%和139%),分泌Th2型细胞因子IL-4数增加了67%;用修饰后平均粒径400 nm微球为佐剂免疫小鼠,IL-2分泌水平是900nm微球为佐剂的1.68倍.
KeywordPla微球 鱼精蛋白 佐剂 膜乳化
Document Type期刊论文
Version出版稿
Identifierhttp://ir.ipe.ac.cn/handle/122111/10214
Collection研究所(批量导入)
Recommended Citation
GB/T 7714
刘玉莹,陈小明,王连艳,等. 鱼精蛋白对PLA微球佐剂的调控[J]. 过程工程学报,2013(04):646-653.
APA 刘玉莹,陈小明,王连艳,袁其朋,&马光辉.(2013).鱼精蛋白对PLA微球佐剂的调控.过程工程学报(04),646-653.
MLA 刘玉莹,et al."鱼精蛋白对PLA微球佐剂的调控".过程工程学报 .04(2013):646-653.
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