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以壳聚糖为基质的智能电荷翻转体系用于紫杉醇的高效输送
马宇峰; 吕丕平; 岳占国; 魏炜; 马光辉; 余蓉
2012
Source Publication过程工程学报
Issue03Pages:460-465
Abstract通过在羧甲基壳聚糖纳米球(CNP)表面修饰三(2-氨基乙基)胺(TAEA)及2,3-二甲基马来酸酐(DMMA),得到针对肿瘤微酸环境响应的智能电荷翻转体系(CNP:TAEA:DMMA纳米球),并用于难溶性抗肿瘤药物紫杉醇(PTX)的高效输送.结果表明,所制纳米球在正常体液(pH7.4)条件下能保留其负电性(11mV),从而减少被巨噬细胞J774A.1摄取;而在肿瘤部位的微酸环境(pH6.8)下,其表面负电性(34.8mV)可迅速转化为正电性(+5mV),促进被肿瘤细胞LLC摄取,提高肿瘤细胞内的药物浓度.与市售注射剂相比,纳米球展现出良好的生物相容性,对肿瘤细胞杀伤效果也明显提高,其半抑制浓度从11.3降低至4.09g/mL,实现了PTX的高效输送.
Keyword电荷翻转 紫杉醇 药物载体 壳聚糖纳米球
Document Type期刊论文
Version出版稿
Identifierhttp://ir.ipe.ac.cn/handle/122111/10250
Collection研究所(批量导入)
Recommended Citation
GB/T 7714
马宇峰,吕丕平,岳占国,等. 以壳聚糖为基质的智能电荷翻转体系用于紫杉醇的高效输送[J]. 过程工程学报,2012(03):460-465.
APA 马宇峰,吕丕平,岳占国,魏炜,马光辉,&余蓉.(2012).以壳聚糖为基质的智能电荷翻转体系用于紫杉醇的高效输送.过程工程学报(03),460-465.
MLA 马宇峰,et al."以壳聚糖为基质的智能电荷翻转体系用于紫杉醇的高效输送".过程工程学报 .03(2012):460-465.
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