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甲氨喋呤自组装温敏胶束的制备及表征
孙飞龙; 王玉霞; 程刚; 韦祎; 马光辉
2013
Source Publication过程工程学报
Issue03Pages:474-480
Abstract利用聚(异丙基丙烯酰胺丙烯酰胺)聚(甲基丙烯酸正丁酯)嵌段共聚物,以透析法制备甲氨喋呤温度敏感型胶束,考察了过膜次数、透析介质更换频率、透析时间和预加入水分等对胶束粒径分布的影响及药物/共聚物投料质量比、透析温度和透析介质对药物包封率的影响,测定了胶束的最低临界溶解温度,对粒径分布和胶束形态进行了表征.结果表明,制备胶束的优化条件为:药物/嵌段共聚物投料质量比1:10,以pH6.8的磷酸盐缓冲液为透析介质,在4℃下每天前12h每隔1h更换透析介质,后12h更换2次,透析3d,所得胶束呈壳核结构的球形,平均粒径为190±15nm,多分散指数为0.16,药物包封率为15%,胶束最低临界溶解温度为41℃.
Keyword两亲性嵌段共聚物 自组装 温敏胶束 水不溶性 甲氨喋呤
Document Type期刊论文
Version出版稿
Identifierhttp://ir.ipe.ac.cn/handle/122111/10361
Collection研究所(批量导入)
Recommended Citation
GB/T 7714
孙飞龙,王玉霞,程刚,等. 甲氨喋呤自组装温敏胶束的制备及表征[J]. 过程工程学报,2013(03):474-480.
APA 孙飞龙,王玉霞,程刚,韦祎,&马光辉.(2013).甲氨喋呤自组装温敏胶束的制备及表征.过程工程学报(03),474-480.
MLA 孙飞龙,et al."甲氨喋呤自组装温敏胶束的制备及表征".过程工程学报 .03(2013):474-480.
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