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快速膜乳化法制备粒径均一的PLGA微球和微囊
田瑞; 王连艳; 吴颉; 张洁; 曾烨婧; 马光辉
2009
Source Publication过程工程学报
Issue04Pages:754-762
Abstract以聚(乳酸-羟基乙酸)(PLGA)为膜材,采用快速膜乳化结合溶剂萃取法制备了胰高血糖素样肽-1(GLP-1)微囊,研究了PLGA分子量对药物装载率、药物活性和体外释放行为的影响.制备均一微球的优化条件为过膜压力1000kPa,过膜次数3次,外水相稳定剂聚乙烯醇浓度19g/L,油水体积比1:5.在此条件下,制备了粒径350nm左右、多分散系数小于0.050的载GLP-1的PLGA微囊,GLP-1包埋率达65%以上,活性保留达85%以上,药物体外释药可达20d.
Keyword聚(乳酸-羟基乙酸) 微球 胰高血糖素样肽-1 微囊 包埋
Indexed ByCSCD
CSCD IDCSCD:3659322
Citation statistics
Cited Times:12[CSCD]   [CSCD Record]
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/10393
Collection研究所(批量导入)
Recommended Citation
GB/T 7714
田瑞,王连艳,吴颉,等. 快速膜乳化法制备粒径均一的PLGA微球和微囊[J]. 过程工程学报,2009(04):754-762.
APA 田瑞,王连艳,吴颉,张洁,曾烨婧,&马光辉.(2009).快速膜乳化法制备粒径均一的PLGA微球和微囊.过程工程学报(04),754-762.
MLA 田瑞,et al."快速膜乳化法制备粒径均一的PLGA微球和微囊".过程工程学报 .04(2009):754-762.
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