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The immunogenicity and protection effect of the BPL-inactivated CA16 vaccine in different animal systems
Alternative TitleHuman Vaccines Immunother.
An, Wen Qi1,2; Su, Zhi Guo2; Pan, Ruo Wen1; Yang, Bao Ping1; Zhang, Yong Chao1; Shi, Liang1; Li, Qing1
2014-03-01
Source PublicationHUMAN VACCINES & IMMUNOTHERAPEUTICS
ISSN2164-5515
Volume10Issue:3Pages:628-639
AbstractWe evaluated the effect of a beta-propiolactone (BPL)-inactivated coxsackievirus A16 (CA16) vaccine, using three immunogenicity evaluation and two animal challenge systems. A CA16 virus strain, named 419, was used as the production strain. Another CA16 strain, named 1131, was isolated an used as the challenge strain in intracerebral inoculation of neonatal mice for the calculation of median lethal dose (LD50). In the passive and maternal antibody-protection challenge systems, all results indicated that the vaccine could protect mouse pups from lethal challenge with the CA16 virus. In the immunogenicity systems, three types of animal (mouse, rat, and cynomolgus monkey), were immunized with the 419/CA16 vaccine. The dose-effect relationship and the antibody-generation routine were described. The CA16 vaccine induced a more potent serum antibody effect in rat than in mouse. The serum antibody titer was detectable more than 63 days after the initial vaccination. We also identified tools to evaluate the effect of the BPL-inactivated CA16 vaccine.; We evaluated the effect of a beta-propiolactone (BPL)-inactivated coxsackievirus A16 (CA16) vaccine, using three immunogenicity evaluation and two animal challenge systems. A CA16 virus strain, named 419, was used as the production strain. Another CA16 strain, named 1131, was isolated an used as the challenge strain in intracerebral inoculation of neonatal mice for the calculation of median lethal dose (LD50). In the passive and maternal antibody-protection challenge systems, all results indicated that the vaccine could protect mouse pups from lethal challenge with the CA16 virus. In the immunogenicity systems, three types of animal (mouse, rat, and cynomolgus monkey), were immunized with the 419/CA16 vaccine. The dose-effect relationship and the antibody-generation routine were described. The CA16 vaccine induced a more potent serum antibody effect in rat than in mouse. The serum antibody titer was detectable more than 63 days after the initial vaccination. We also identified tools to evaluate the effect of the BPL-inactivated CA16 vaccine.
KeywordCoxsackievirus A16 Enterovirus Vaccine Challenge Systems Immunogenicity
SubtypeArticle
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
DOI10.4161/hv.27295
URL查看原文 ; 查看原文
Indexed BySCI
Language英语
WOS KeywordCOXSACKIEVIRUS A16 ; ENTEROVIRUS 71 ; NEUTRALIZING ANTIBODIES ; BETA-PROPIOLACTONE ; RHESUS-MONKEYS ; VIRUS VACCINES ; MOUTH-DISEASE ; MOUSE MODEL ; MICE ; INFECTION
WOS Research AreaBiotechnology & Applied Microbiology ; Immunology
WOS SubjectBiotechnology & Applied Microbiology ; Immunology
WOS IDWOS:000336653800024
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Document Type期刊论文
Version出版稿
Identifierhttp://ir.ipe.ac.cn/handle/122111/10877
Collection研究所(批量导入)
Affiliation1.Hualan Biol Engn Inc, Xinxiang, Peoples R China
2.Chinese Acad Sci, Inst Proc Engn, Natl Key Lab Biochem Engn, Beijing, Peoples R China
Recommended Citation
GB/T 7714
An, Wen Qi,Su, Zhi Guo,Pan, Ruo Wen,et al. The immunogenicity and protection effect of the BPL-inactivated CA16 vaccine in different animal systems[J]. HUMAN VACCINES & IMMUNOTHERAPEUTICS,2014,10(3):628-639.
APA An, Wen Qi.,Su, Zhi Guo.,Pan, Ruo Wen.,Yang, Bao Ping.,Zhang, Yong Chao.,...&Li, Qing.(2014).The immunogenicity and protection effect of the BPL-inactivated CA16 vaccine in different animal systems.HUMAN VACCINES & IMMUNOTHERAPEUTICS,10(3),628-639.
MLA An, Wen Qi,et al."The immunogenicity and protection effect of the BPL-inactivated CA16 vaccine in different animal systems".HUMAN VACCINES & IMMUNOTHERAPEUTICS 10.3(2014):628-639.
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