CAS OpenIR  > 研究所(批量导入)
Folic acid-conjugated glucose and dextran coated iron oxide nanoparticles as MRI contrast agents for diagnosis and treatment response of rheumatoid arthritis
Alternative TitleJ. Mat. Chem. B
Dai, Fengying1; Du, Meihong2; Liu, Yingguo1; Liu, Guiying3; Liu, Qingjun2; Zhang, Xin1
2014
Source PublicationJOURNAL OF MATERIALS CHEMISTRY B
ISSN2050-750X
Volume2Issue:16Pages:2240-2247
AbstractCoating superparamagnetic iron oxide (SPIO) with dextran increases the stability of the magnetic nanoparticles during blood circulation, yet this is accompanied by an increase in the particle size and the vascular permeability efficiency of the SPIO nanoparticles into the joints decreases. In our study, the thickness of the dextran coated onto SPIO (dex-SPIO) was optimized without affecting the magnetic quality of iron oxide by adding a suitable amount of glucose into the crystal growth process. To further improve the signal enhancement effect of this glucose and dextran coated SPIO (glu-dex-SPIO) for the detection of the inflammatory site of arthritis, folic acid (FA) was conjugated to glu-dex-SPIO. This FA glu-dex-SPIO was used as a negative contrast agent for MRI to visualize the antigen induce arthritis (AIA) model in rats using a 7 T MR scans. MR imaging revealed more significant differences between the synovium and surrounding tissues with FA glu-dex-SPIO than when using the non-targeting glu-dex-SPIO over a long period of time (24 h) after intravenous injection. Moreover, the therapeutic efficacy of the cyclooxygenase 2 (COX-2) inhibitor treatment of the inflamed joints also could be confirmed by using FA glu-dex-SPIO enhanced MRI, indicating that this type of nanoparticles could also have potential as a contrast agent for measuring the treatment response of rheumatoid arthritis.; Coating superparamagnetic iron oxide (SPIO) with dextran increases the stability of the magnetic nanoparticles during blood circulation, yet this is accompanied by an increase in the particle size and the vascular permeability efficiency of the SPIO nanoparticles into the joints decreases. In our study, the thickness of the dextran coated onto SPIO (dex-SPIO) was optimized without affecting the magnetic quality of iron oxide by adding a suitable amount of glucose into the crystal growth process. To further improve the signal enhancement effect of this glucose and dextran coated SPIO (glu-dex-SPIO) for the detection of the inflammatory site of arthritis, folic acid (FA) was conjugated to glu-dex-SPIO. This FA glu-dex-SPIO was used as a negative contrast agent for MRI to visualize the antigen induce arthritis (AIA) model in rats using a 7 T MR scans. MR imaging revealed more significant differences between the synovium and surrounding tissues with FA glu-dex-SPIO than when using the non-targeting glu-dex-SPIO over a long period of time (24 h) after intravenous injection. Moreover, the therapeutic efficacy of the cyclooxygenase 2 (COX-2) inhibitor treatment of the inflamed joints also could be confirmed by using FA glu-dex-SPIO enhanced MRI, indicating that this type of nanoparticles could also have potential as a contrast agent for measuring the treatment response of rheumatoid arthritis.
KeywordFollow-up In-vitro One-pot Ferumoxides Ferumoxtran Size
SubtypeArticle
WOS HeadingsScience & Technology ; Technology
DOI10.1039/c3tb21732a
URL查看原文
Indexed BySCI
Language英语
WOS KeywordFOLLOW-UP ; IN-VITRO ; ONE-POT ; FERUMOXIDES ; FERUMOXTRAN ; SIZE
WOS Research AreaMaterials Science
WOS SubjectMaterials Science, Biomaterials
WOS IDWOS:000334120800006
Citation statistics
Cited Times:26[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Version出版稿
Identifierhttp://ir.ipe.ac.cn/handle/122111/10893
Collection研究所(批量导入)
Affiliation1.Chinese Acad Sci, Inst Proc Engn, Natl Key Lab Biochem Engn, Beijing 100190, Peoples R China
2.Beijing Ctr Phys & Chem Anal, Beijing 100871, Peoples R China
3.Capital Med Univ, Affiliated Beijing Anzhen Hosp, Dept Pediat, Beijing 100029, Peoples R China
Recommended Citation
GB/T 7714
Dai, Fengying,Du, Meihong,Liu, Yingguo,et al. Folic acid-conjugated glucose and dextran coated iron oxide nanoparticles as MRI contrast agents for diagnosis and treatment response of rheumatoid arthritis[J]. JOURNAL OF MATERIALS CHEMISTRY B,2014,2(16):2240-2247.
APA Dai, Fengying,Du, Meihong,Liu, Yingguo,Liu, Guiying,Liu, Qingjun,&Zhang, Xin.(2014).Folic acid-conjugated glucose and dextran coated iron oxide nanoparticles as MRI contrast agents for diagnosis and treatment response of rheumatoid arthritis.JOURNAL OF MATERIALS CHEMISTRY B,2(16),2240-2247.
MLA Dai, Fengying,et al."Folic acid-conjugated glucose and dextran coated iron oxide nanoparticles as MRI contrast agents for diagnosis and treatment response of rheumatoid arthritis".JOURNAL OF MATERIALS CHEMISTRY B 2.16(2014):2240-2247.
Files in This Item:
File Name/Size DocType Version Access License
Folic acid-conjugate(1024KB) 限制开放CC BY-NC-SAApplication Full Text
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Dai, Fengying]'s Articles
[Du, Meihong]'s Articles
[Liu, Yingguo]'s Articles
Baidu academic
Similar articles in Baidu academic
[Dai, Fengying]'s Articles
[Du, Meihong]'s Articles
[Liu, Yingguo]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Dai, Fengying]'s Articles
[Du, Meihong]'s Articles
[Liu, Yingguo]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.