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PLGA-lipid liposphere as a promising platform for oral delivery of proteins
Alternative TitleColloid Surf. B-Biointerfaces
Ma, Tongtong1,2; Wang, Lianyan2; TingyuanYang2; Wang, Dong2; Ma, Guanghui2; Wang, Siling1
2014-05-01
Source PublicationCOLLOIDS AND SURFACES B-BIOINTERFACES
ISSN0927-7765
Volume117Issue:1Pages:512-519
AbstractThe main challenge in the oral delivery of protein drugs is to enhance their oral bioavailability. Herein, we report the uniform-sized liposphere prepared by premix membrane emulsification combined with W-1/O/W-2 double-emulsion method as a potential oral carrier for proteins. The protein-loaded liposphere was composed of a hydrophobic poly (D, L-lactide-co-glycolide) (PLGA) core and the lipid molecules self-assembled at the interface of W-1/O and O/W-2. During the preparation, the protein structure was effectively maintained. Compared with PLGA microsphere, the liposphere achieved a higher loading capacity (LC, 20.18%), entrapment efficiency (EE, 90.82%) and a lower initial burst (24.73%). Importantly, the lipospheres also showed high transcytotic efficiency with human microfold cell (M cell) model, leading to a potential enhancement of intestinal absorption. This result, together with the above studies supported that the PLGA-lipid liposphere could be a promising platform for enhancing the proteins oral bioavailability. (C) 2014 Elsevier B.V. All rights reserved.; The main challenge in the oral delivery of protein drugs is to enhance their oral bioavailability. Herein, we report the uniform-sized liposphere prepared by premix membrane emulsification combined with W-1/O/W-2 double-emulsion method as a potential oral carrier for proteins. The protein-loaded liposphere was composed of a hydrophobic poly (D, L-lactide-co-glycolide) (PLGA) core and the lipid molecules self-assembled at the interface of W-1/O and O/W-2. During the preparation, the protein structure was effectively maintained. Compared with PLGA microsphere, the liposphere achieved a higher loading capacity (LC, 20.18%), entrapment efficiency (EE, 90.82%) and a lower initial burst (24.73%). Importantly, the lipospheres also showed high transcytotic efficiency with human microfold cell (M cell) model, leading to a potential enhancement of intestinal absorption. This result, together with the above studies supported that the PLGA-lipid liposphere could be a promising platform for enhancing the proteins oral bioavailability. (C) 2014 Elsevier B.V. All rights reserved.
KeywordLipospheres Uniform Oral Bioavailability Proteins
SubtypeArticle
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine ; Physical Sciences ; Technology
DOI10.1016/j.colsurfb.2014.02.039
URL查看原文
Indexed BySCI
Language英语
WOS KeywordDRUG-DELIVERY ; NANOPARTICLES ; MICROSPHERES ; PACLITAXEL ; RELEASE ; SYSTEMS
WOS Research AreaBiophysics ; Chemistry ; Materials Science
WOS SubjectBiophysics ; Chemistry, Physical ; Materials Science, Biomaterials
WOS IDWOS:000336018700067
Citation statistics
Cited Times:24[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Version出版稿
Identifierhttp://ir.ipe.ac.cn/handle/122111/10945
Collection研究所(批量导入)
Affiliation1.Shenyang Pharmaceut Univ, Dept Pharmaceut, Shenyang 110016, Peoples R China
2.Chinese Acad Sci, Inst Proc Engn, PLA Key Lab Biopharmaceut Prod & Formulat Engn, Natl Key Lab Biochem Engn, Beijing 100190, Peoples R China
Recommended Citation
GB/T 7714
Ma, Tongtong,Wang, Lianyan,TingyuanYang,et al. PLGA-lipid liposphere as a promising platform for oral delivery of proteins[J]. COLLOIDS AND SURFACES B-BIOINTERFACES,2014,117(1):512-519.
APA Ma, Tongtong,Wang, Lianyan,TingyuanYang,Wang, Dong,Ma, Guanghui,&Wang, Siling.(2014).PLGA-lipid liposphere as a promising platform for oral delivery of proteins.COLLOIDS AND SURFACES B-BIOINTERFACES,117(1),512-519.
MLA Ma, Tongtong,et al."PLGA-lipid liposphere as a promising platform for oral delivery of proteins".COLLOIDS AND SURFACES B-BIOINTERFACES 117.1(2014):512-519.
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