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Preparation and enzymatic application of flower-like hybrid microcapsules through a biomimetic mineralization approach
Alternative TitleJ. Mat. Chem. B
Shi, Jiafu1,2,3; Zhang, Shaohua1,3; Wang, Xiaoli1,3; Yang, Chen1,3; Jiang, Zhongyi1,3,4
2014
Source PublicationJOURNAL OF MATERIALS CHEMISTRY B
ISSN2050-750X
Volume2Issue:27Pages:4289-4296
AbstractFast and quantitative adsorption of molecules may confer hybrid microcapsules high performance in specific applications, such as biocatalysis, biosensing, drug delivery, and so on. Engineering the chemical/topological structures of the capsule wall renders great potential to achieve this goal. In the present study, flower-like microcapsules are prepared through a biomimetic mineralization approach. Briefly, protein-hybrid microflowers are firstly synthesized through enzyme-induced precipitation of Cu-3(PO4)(2), which are subsequently utilized as templates for alternative deposition of the protamine layer and the silica layer through biomimetic silicification assisted by layer-by-layer (LbL) assembly. After treatment with EDTA, the flower-like protamine/silica hybrid (FPSH) microcapsules are obtained. Additionally, the hybrid capsule wall also endows the FPSH microcapsules with desirable pH, temperature and storage stability. Hopefully, our approach may provide a promising alternative to increase the efficiency of catalysis, drug delivery, etc.; Fast and quantitative adsorption of molecules may confer hybrid microcapsules high performance in specific applications, such as biocatalysis, biosensing, drug delivery, and so on. Engineering the chemical/topological structures of the capsule wall renders great potential to achieve this goal. In the present study, flower-like microcapsules are prepared through a biomimetic mineralization approach. Briefly, protein-hybrid microflowers are firstly synthesized through enzyme-induced precipitation of Cu-3(PO4)(2), which are subsequently utilized as templates for alternative deposition of the protamine layer and the silica layer through biomimetic silicification assisted by layer-by-layer (LbL) assembly. After treatment with EDTA, the flower-like protamine/silica hybrid (FPSH) microcapsules are obtained. Additionally, the hybrid capsule wall also endows the FPSH microcapsules with desirable pH, temperature and storage stability. Hopefully, our approach may provide a promising alternative to increase the efficiency of catalysis, drug delivery, etc.
KeywordDrug-delivery Capsules Immobilization Nanoflowers Biomineralization Encapsulation Nanocapsules Nanoparticles Permeability Nanospheres
SubtypeArticle
WOS HeadingsScience & Technology ; Technology
DOI10.1039/c4tb00507d
URL查看原文
Indexed BySCI
Language英语
WOS KeywordDRUG-DELIVERY ; CAPSULES ; IMMOBILIZATION ; NANOFLOWERS ; BIOMINERALIZATION ; ENCAPSULATION ; NANOCAPSULES ; NANOPARTICLES ; PERMEABILITY ; NANOSPHERES
WOS Research AreaMaterials Science
WOS SubjectMaterials Science, Biomaterials
WOS IDWOS:000338124900009
Citation statistics
Cited Times:21[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Version出版稿
Identifierhttp://ir.ipe.ac.cn/handle/122111/10956
Collection研究所(批量导入)
Affiliation1.Tianjin Univ, Sch Chem Engn & Technol, Key Lab Green Chem Technol, Minist Educ, Tianjin 300072, Peoples R China
2.Tianjin Univ, Sch Environm Sci & Engn, Tianjin 300072, Peoples R China
3.Collaborat Innovat Ctr Chem Sci & Engn Tianjin, Tianjin 300072, Peoples R China
4.Chinese Acad Sci, Inst Proc Engn, Natl Key Lab Biochem Engn, Beijing 100190, Peoples R China
Recommended Citation
GB/T 7714
Shi, Jiafu,Zhang, Shaohua,Wang, Xiaoli,et al. Preparation and enzymatic application of flower-like hybrid microcapsules through a biomimetic mineralization approach[J]. JOURNAL OF MATERIALS CHEMISTRY B,2014,2(27):4289-4296.
APA Shi, Jiafu,Zhang, Shaohua,Wang, Xiaoli,Yang, Chen,&Jiang, Zhongyi.(2014).Preparation and enzymatic application of flower-like hybrid microcapsules through a biomimetic mineralization approach.JOURNAL OF MATERIALS CHEMISTRY B,2(27),4289-4296.
MLA Shi, Jiafu,et al."Preparation and enzymatic application of flower-like hybrid microcapsules through a biomimetic mineralization approach".JOURNAL OF MATERIALS CHEMISTRY B 2.27(2014):4289-4296.
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