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Merging of covalent cross-linking and biomimetic mineralization into an LBL self-assembly process for the construction of robust organic-inorganic hybrid microcapsules
Alternative TitleJ. Mat. Chem. B
Tian, Chunyong1,2; Zhang, Chunhong1; Wu, Hong1,4; Song, Yixuan1; Shi, Jiafu3; Wang, Xiaoli1; Song, Xiaokai1; Yang, Chen1; Jiang, Zhongyi1,2,4
2014
Source PublicationJOURNAL OF MATERIALS CHEMISTRY B
ISSN2050-750X
Volume2Issue:27Pages:4346-4355
AbstractA mild and efficient method for the construction of robust organic-inorganic hybrid microcapsules was developed by merging of covalent cross-linking and biomimetic mineralization into a layer-by-layer (LBL) self-assembly process. The diatom cell-inspired microcapsule structure had a biocompatible inner organic layer which could create a suitable microenvironment for biologically active substances inside the microcapsules and an inorganic layer which could function as a supporting membrane to maintain the intact morphology of the microcapsules. When in 40% PSS solution, only 5% of the hybrid microcapsules were deformed indicating that the hybrid microcapsule had a higher mechanical stability. The combination of the advantages of both the organic layer and the inorganic layer was applied for the immobilization of catalase (CAT). After being reused 7 times, the CAT in the hybrid microcapsules retained 78% of its initial activity. A buffering effect was created by the capsule wall and the immobilized CAT had a higher pH stability than the free CAT. After storing for 45 days, the CAT in the hybrid microcapsules retained 78% of its initial activity. It is envisaged that the as-prepared hybrid microcapsules can be extended to many applications such as biocatalysis, drug/gene delivery and biosensor fields.; A mild and efficient method for the construction of robust organic-inorganic hybrid microcapsules was developed by merging of covalent cross-linking and biomimetic mineralization into a layer-by-layer (LBL) self-assembly process. The diatom cell-inspired microcapsule structure had a biocompatible inner organic layer which could create a suitable microenvironment for biologically active substances inside the microcapsules and an inorganic layer which could function as a supporting membrane to maintain the intact morphology of the microcapsules. When in 40% PSS solution, only 5% of the hybrid microcapsules were deformed indicating that the hybrid microcapsule had a higher mechanical stability. The combination of the advantages of both the organic layer and the inorganic layer was applied for the immobilization of catalase (CAT). After being reused 7 times, the CAT in the hybrid microcapsules retained 78% of its initial activity. A buffering effect was created by the capsule wall and the immobilized CAT had a higher pH stability than the free CAT. After storing for 45 days, the CAT in the hybrid microcapsules retained 78% of its initial activity. It is envisaged that the as-prepared hybrid microcapsules can be extended to many applications such as biocatalysis, drug/gene delivery and biosensor fields.
KeywordMulti Layers Silica Polymer Encapsulation Surfaces Immobilization Capsules Coatings Delivery Diatoms
SubtypeArticle
WOS HeadingsScience & Technology ; Technology
DOI10.1039/c4tb00243a
URL查看原文
Indexed BySCI
Language英语
WOS KeywordMULTI LAYERS ; SILICA ; POLYMER ; ENCAPSULATION ; SURFACES ; IMMOBILIZATION ; CAPSULES ; COATINGS ; DELIVERY ; DIATOMS
WOS Research AreaMaterials Science
WOS SubjectMaterials Science, Biomaterials
WOS IDWOS:000338124900016
Citation statistics
Cited Times:16[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Version出版稿
Identifierhttp://ir.ipe.ac.cn/handle/122111/10967
Collection研究所(批量导入)
Affiliation1.Tianjin Univ, Sch Chem Engn & Technol, Minist Educ, Key Lab Green Chem Technol, Tianjin 300072, Peoples R China
2.Chinese Acad Sci, Inst Proc Engn, Natl Key Lab Biochem Engn, Beijing 100190, Peoples R China
3.Tianjin Univ, Sch Environm Sci & Engn, Tianjin 300072, Peoples R China
4.Collaborat Innovat Ctr Chem Sci & Engn Tianjin, Tianjin 300072, Peoples R China
Recommended Citation
GB/T 7714
Tian, Chunyong,Zhang, Chunhong,Wu, Hong,et al. Merging of covalent cross-linking and biomimetic mineralization into an LBL self-assembly process for the construction of robust organic-inorganic hybrid microcapsules[J]. JOURNAL OF MATERIALS CHEMISTRY B,2014,2(27):4346-4355.
APA Tian, Chunyong.,Zhang, Chunhong.,Wu, Hong.,Song, Yixuan.,Shi, Jiafu.,...&Jiang, Zhongyi.(2014).Merging of covalent cross-linking and biomimetic mineralization into an LBL self-assembly process for the construction of robust organic-inorganic hybrid microcapsules.JOURNAL OF MATERIALS CHEMISTRY B,2(27),4346-4355.
MLA Tian, Chunyong,et al."Merging of covalent cross-linking and biomimetic mineralization into an LBL self-assembly process for the construction of robust organic-inorganic hybrid microcapsules".JOURNAL OF MATERIALS CHEMISTRY B 2.27(2014):4346-4355.
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