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Design, preparation and application of nucleic acid delivery carriers
Alternative TitleBiotechnol. Adv.
Yang, Jun1; Liu, Hongmei1,2; Zhang, Xin1
2014-07-01
Source PublicationBIOTECHNOLOGY ADVANCES
ISSN0734-9750
Volume32Issue:4Pages:804-817
AbstractGene delivery vectors must deliver their cargoes into the cytosol or the nucleus, where DNA or siRNA functions in vivo. Therefore it is crucial for the rational design of the nucleic acid delivery carriers. Compared with viral vectors, non-viral vectors have overcome some fatal defections in gene therapy. Whereas the most important issue for the non-viral vectors is the low transfection efficiency, which hinders the progress of non-viral carriers. Sparked by the structures of the virus and understanding of the process of virus infection, various biomimic structures of non-viral carriers were designed and prepared to improve the transfection issues in vitro and in vivo. However, less impressive results are achieved. In this review, we will investigate the evolution of the virus-mimicking carriers of nucleic acids for gene therapy, especially in cancer therapy; explore and discuss the relationship between the structures, materials and functions of the carriers, to provide guidance for establishing safe and highly efficient non-viral carriers for gene therapy. (C) 2013 Elsevier Inc. All rights reserved.; Gene delivery vectors must deliver their cargoes into the cytosol or the nucleus, where DNA or siRNA functions in vivo. Therefore it is crucial for the rational design of the nucleic acid delivery carriers. Compared with viral vectors, non-viral vectors have overcome some fatal defections in gene therapy. Whereas the most important issue for the non-viral vectors is the low transfection efficiency, which hinders the progress of non-viral carriers. Sparked by the structures of the virus and understanding of the process of virus infection, various biomimic structures of non-viral carriers were designed and prepared to improve the transfection issues in vitro and in vivo. However, less impressive results are achieved. In this review, we will investigate the evolution of the virus-mimicking carriers of nucleic acids for gene therapy, especially in cancer therapy; explore and discuss the relationship between the structures, materials and functions of the carriers, to provide guidance for establishing safe and highly efficient non-viral carriers for gene therapy. (C) 2013 Elsevier Inc. All rights reserved.
KeywordGene Delivery Non-viral Vectors Liposome Polymersome Dendrimersome
SubtypeReview
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
DOI10.1016/j.biotechadv.2013.11.004
URL查看原文
Indexed BySCI
Language英语
WOS KeywordBIOREDUCIBLE POLY(AMIDO AMINE)S ; LIPOSOME-DNA COMPLEXES ; LOW-MOLECULAR-WEIGHT ; VITRO GENE DELIVERY ; POLY-L-LYSINE ; IN-VITRO ; SIRNA DELIVERY ; CANCER-THERAPY ; JANUS DENDRIMERS ; PLASMID DNA
WOS Research AreaBiotechnology & Applied Microbiology
WOS SubjectBiotechnology & Applied Microbiology
WOS IDWOS:000338818300011
Citation statistics
Cited Times:39[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Version出版稿
Identifierhttp://ir.ipe.ac.cn/handle/122111/11006
Collection研究所(批量导入)
Affiliation1.Chinese Acad Sci, Inst Proc Engn, Natl Key Lab Biochem Engn, Beijing 100190, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Yang, Jun,Liu, Hongmei,Zhang, Xin. Design, preparation and application of nucleic acid delivery carriers[J]. BIOTECHNOLOGY ADVANCES,2014,32(4):804-817.
APA Yang, Jun,Liu, Hongmei,&Zhang, Xin.(2014).Design, preparation and application of nucleic acid delivery carriers.BIOTECHNOLOGY ADVANCES,32(4),804-817.
MLA Yang, Jun,et al."Design, preparation and application of nucleic acid delivery carriers".BIOTECHNOLOGY ADVANCES 32.4(2014):804-817.
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