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Biocompatibility and characteristics of theophylline/carboxymethyl chitosan microspheres for pulmonary drug delivery
Alternative TitlePolym. Int.
Zhang, Wei Fen1; Zhao, Xin Tong2; Zhao, Qing Sheng3; Zha, Sheng Hua3; Liu, Dong Mei1; Zheng, Zeng Juan1; Li, Wen Tao1; Zhou, Hui Yun4; Yan, Fang1
2014-06-01
Source PublicationPOLYMER INTERNATIONAL
ISSN0959-8103
Volume63Issue:6Pages:1035-1040
AbstractThe main aim was to evaluate the biocompatibility of theophylline/carboxymethyl chitosan/beta-cyclodextrin microspheres made by spray drying for pulmonary delivery. Haemolysis tests and cell culture experiments were used to determine blood and cell biocompatibility, and in vivo implantation experiments were used to examine tissue biocompatibility. The theophylline/carboxymethyl chitosan/beta-cyclodextrin microspheres were spherical in shape with a smooth or wrinkled surface, and showed no haemolysis activity. The cytotoxicity was dependent on concentration and showed no toxicity at low concentration. The results of implantation indicated that the inflammatory reaction gradually lessened and disappeared and had no significant difference from that of an operative suture. Therefore, theophylline/carboxymethyl chitosan/beta-cyclodextrin microspheres possess good biocompatibility and can be used as a promising carrier for pulmonary drug delivery. (c) 2013 Society of Chemical Industry; The main aim was to evaluate the biocompatibility of theophylline/carboxymethyl chitosan/beta-cyclodextrin microspheres made by spray drying for pulmonary delivery. Haemolysis tests and cell culture experiments were used to determine blood and cell biocompatibility, and in vivo implantation experiments were used to examine tissue biocompatibility. The theophylline/carboxymethyl chitosan/beta-cyclodextrin microspheres were spherical in shape with a smooth or wrinkled surface, and showed no haemolysis activity. The cytotoxicity was dependent on concentration and showed no toxicity at low concentration. The results of implantation indicated that the inflammatory reaction gradually lessened and disappeared and had no significant difference from that of an operative suture. Therefore, theophylline/carboxymethyl chitosan/beta-cyclodextrin microspheres possess good biocompatibility and can be used as a promising carrier for pulmonary drug delivery. (c) 2013 Society of Chemical Industry
KeywordTheophylline Microspheres Biocompatibility Carboxymethyl Chitosan
SubtypeArticle
WOS HeadingsScience & Technology ; Physical Sciences
DOI10.1002/pi.4606
URL查看原文
Indexed BySCI
Language英语
WOS KeywordCYCLODEXTRIN MICROSPHERES ; N,O-CARBOXYMETHYL CHITOSAN ; RELEASE ; HYDROGEL ; CARRIERS
WOS Research AreaPolymer Science
WOS SubjectPolymer Science
WOS IDWOS:000335568500013
Citation statistics
Cited Times:5[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Version出版稿
Identifierhttp://ir.ipe.ac.cn/handle/122111/11037
Collection研究所(批量导入)
Affiliation1.Weifang Med Univ, Dept Pharm & Biol Sci, Weifang 261053, Shandong, Peoples R China
2.Shandong Univ, Sch Med, Jinan 261052, Peoples R China
3.Chinese Acad Sci, Inst Proc Engn, Natl Key Lab Biochem Engn, Beijing 100190, Peoples R China
4.Henan Univ Sci & Technol, Chem Engn & Pharmaceut Coll, Luoyang 471003, Peoples R China
Recommended Citation
GB/T 7714
Zhang, Wei Fen,Zhao, Xin Tong,Zhao, Qing Sheng,et al. Biocompatibility and characteristics of theophylline/carboxymethyl chitosan microspheres for pulmonary drug delivery[J]. POLYMER INTERNATIONAL,2014,63(6):1035-1040.
APA Zhang, Wei Fen.,Zhao, Xin Tong.,Zhao, Qing Sheng.,Zha, Sheng Hua.,Liu, Dong Mei.,...&Yan, Fang.(2014).Biocompatibility and characteristics of theophylline/carboxymethyl chitosan microspheres for pulmonary drug delivery.POLYMER INTERNATIONAL,63(6),1035-1040.
MLA Zhang, Wei Fen,et al."Biocompatibility and characteristics of theophylline/carboxymethyl chitosan microspheres for pulmonary drug delivery".POLYMER INTERNATIONAL 63.6(2014):1035-1040.
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