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Nanoengineering of Stimuli-Responsive Protein-Based Biomimetic Protocells as Versatile Drug Delivery Tools
Alternative TitleChem.-Eur. J.
Zhao, Fenfang1,2; Shen, Guizhi1; Chen, Chengjun1; Xing, Ruirui1; Zou, Qianli1; Ma, Guanghui1; Yan, Xuehai1
2014-06-02
Source PublicationCHEMISTRY-A EUROPEAN JOURNAL
ISSN0947-6539
Volume20Issue:23Pages:6880-6887
AbstractWe present a general strategy to nanoengineer protein-based colloidal spheres (biomimetic protocells) as versatile delivery carriers with stimuli responsiveness by the electrostatic assembly of binary components (proteins and polypeptides) in association with intermolecular disulfide cross-linking. The size of the colloidal spheres, ranging from nanoscale to microscale, is readily tuned through parameters like protein and polypeptide concentration, the ratio between both, pH, and so on. Moreover, such colloidal spheres show versatile encapsulation of various guest molecules including small organic molecules and biomacromolecules. The pH and redox dual-responsiveness facilitates the rapid release of the payload in an acidic and reductant-enriched ambient such as in lysosomes. Thus, nanoengineering of protein-based biomimetic protocells opens a new alternative avenue for developing delivery vehicles with multifunctional properties towards a range of therapeutic and diagnostic applications.; We present a general strategy to nanoengineer protein-based colloidal spheres (biomimetic protocells) as versatile delivery carriers with stimuli responsiveness by the electrostatic assembly of binary components (proteins and polypeptides) in association with intermolecular disulfide cross-linking. The size of the colloidal spheres, ranging from nanoscale to microscale, is readily tuned through parameters like protein and polypeptide concentration, the ratio between both, pH, and so on. Moreover, such colloidal spheres show versatile encapsulation of various guest molecules including small organic molecules and biomacromolecules. The pH and redox dual-responsiveness facilitates the rapid release of the payload in an acidic and reductant-enriched ambient such as in lysosomes. Thus, nanoengineering of protein-based biomimetic protocells opens a new alternative avenue for developing delivery vehicles with multifunctional properties towards a range of therapeutic and diagnostic applications.
KeywordColloids Drug Delivery Nanostructures Polypeptides Proteins
SubtypeArticle
WOS HeadingsScience & Technology ; Physical Sciences
DOI10.1002/chem.201400348
URL查看原文
Indexed BySCI
Language英语
WOS KeywordALBUMIN HSA NANOPARTICLES ; SERUM-ALBUMIN ; MICROCAPSULES ; RELEASE ; SPHERES ; SHELLS ; PH ; DOXORUBICIN ; ASSEMBLIES ; REDUCTION
WOS Research AreaChemistry
WOS SubjectChemistry, Multidisciplinary
WOS IDWOS:000337574800010
Citation statistics
Cited Times:59[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Version出版稿
Identifierhttp://ir.ipe.ac.cn/handle/122111/11049
Collection研究所(批量导入)
Affiliation1.Chinese Acad Sci, Inst Proc Engn, Natl Key Lab Biochem Engn, Beijing 100190, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Zhao, Fenfang,Shen, Guizhi,Chen, Chengjun,et al. Nanoengineering of Stimuli-Responsive Protein-Based Biomimetic Protocells as Versatile Drug Delivery Tools[J]. CHEMISTRY-A EUROPEAN JOURNAL,2014,20(23):6880-6887.
APA Zhao, Fenfang.,Shen, Guizhi.,Chen, Chengjun.,Xing, Ruirui.,Zou, Qianli.,...&Yan, Xuehai.(2014).Nanoengineering of Stimuli-Responsive Protein-Based Biomimetic Protocells as Versatile Drug Delivery Tools.CHEMISTRY-A EUROPEAN JOURNAL,20(23),6880-6887.
MLA Zhao, Fenfang,et al."Nanoengineering of Stimuli-Responsive Protein-Based Biomimetic Protocells as Versatile Drug Delivery Tools".CHEMISTRY-A EUROPEAN JOURNAL 20.23(2014):6880-6887.
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