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A rheumatoid arthritis magnetic resonance imaging contrast agent based on folic acid conjugated PEG-b- PAA@SPION
Alternative TitleJ. Mat. Chem. B
Zhong, Yanqi1,2; Dai, Fengying1; Deng, Heng1,2; Du, Meihong3; Zhang, Xiaoning4; Liu, Qingjun3; Zhang, Xin1
2014
Source PublicationJOURNAL OF MATERIALS CHEMISTRY B
ISSN2050-750X
Volume2Issue:19Pages:2938-2946
AbstractSuperparamagnetic iron oxide nanoparticles (SPIONs) offer unique properties for magnetic resonance imaging (MRI). Targeting imaging of rheumatoid arthritis in vivo requires a specific, magnetic sensitive and ultra-stable MRI contrast agent. In this study, SPIONs with a preferable colloid stability and optimized size were obtained by using an in situ polyol method with the diblock copolymer PEG-b-PAA acting as a surface ligand. Increasing the degree of polymerization (DP) of PAA from 18 to 36 to 57 led to the decreasing size of the iron oxide nanoparticles from 52 nm to 17 nm to 9 nm, respectively. Folic acid was conjugated onto PEG-PAA(x)@ SPION as a specific targeting molecule for activated macrophages in a rheumatoid arthritis joint. To evaluate the stability and magnetic properties of the particle, a series of tests were conducted to evaluate and optimize the nanoparticles. In vitro endocytosis experiments confirmed the better performance of the folic acid conjugated SPIONs than the non-folic acid modified SPIONs. In vivo MRI clearly demonstrated the significant signal diminishment of the arthritis joint in antigen induced arthritis (AIA) rats by intravenous injection of the optimized nanoparticles FA-PEG-bPAA(36)@ SPION. These results indicated that FA-PEG-b-PAA(36)@ SPION could serve as a promising candidate for the MRI of rheumatoid arthritis.; Superparamagnetic iron oxide nanoparticles (SPIONs) offer unique properties for magnetic resonance imaging (MRI). Targeting imaging of rheumatoid arthritis in vivo requires a specific, magnetic sensitive and ultra-stable MRI contrast agent. In this study, SPIONs with a preferable colloid stability and optimized size were obtained by using an in situ polyol method with the diblock copolymer PEG-b-PAA acting as a surface ligand. Increasing the degree of polymerization (DP) of PAA from 18 to 36 to 57 led to the decreasing size of the iron oxide nanoparticles from 52 nm to 17 nm to 9 nm, respectively. Folic acid was conjugated onto PEG-PAA(x)@ SPION as a specific targeting molecule for activated macrophages in a rheumatoid arthritis joint. To evaluate the stability and magnetic properties of the particle, a series of tests were conducted to evaluate and optimize the nanoparticles. In vitro endocytosis experiments confirmed the better performance of the folic acid conjugated SPIONs than the non-folic acid modified SPIONs. In vivo MRI clearly demonstrated the significant signal diminishment of the arthritis joint in antigen induced arthritis (AIA) rats by intravenous injection of the optimized nanoparticles FA-PEG-bPAA(36)@ SPION. These results indicated that FA-PEG-b-PAA(36)@ SPION could serve as a promising candidate for the MRI of rheumatoid arthritis.
KeywordIron-oxide Nanoparticles Intracellular Uptake Cancer Size Macrophages Relaxivity Delivery Shape Mri
SubtypeArticle
WOS HeadingsScience & Technology ; Technology
DOI10.1039/c4tb00085d
URL查看原文
Indexed BySCI
Language英语
WOS KeywordIRON-OXIDE NANOPARTICLES ; INTRACELLULAR UPTAKE ; CANCER ; SIZE ; MACROPHAGES ; RELAXIVITY ; DELIVERY ; SHAPE ; MRI
WOS Research AreaMaterials Science
WOS SubjectMaterials Science, Biomaterials
WOS IDWOS:000335225100015
Citation statistics
Cited Times:17[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Version出版稿
Identifierhttp://ir.ipe.ac.cn/handle/122111/11057
Collection研究所(批量导入)
Affiliation1.Chinese Acad Sci, Inst Proc Engn, Natl Key Lab Biochem Engn, Beijing 100190, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Beijing Ctr Phys & Chem Anal, Beijing 100089, Peoples R China
4.Tsinghua Univ, Sch Med, Beijing 100084, Peoples R China
Recommended Citation
GB/T 7714
Zhong, Yanqi,Dai, Fengying,Deng, Heng,et al. A rheumatoid arthritis magnetic resonance imaging contrast agent based on folic acid conjugated PEG-b- PAA@SPION[J]. JOURNAL OF MATERIALS CHEMISTRY B,2014,2(19):2938-2946.
APA Zhong, Yanqi.,Dai, Fengying.,Deng, Heng.,Du, Meihong.,Zhang, Xiaoning.,...&Zhang, Xin.(2014).A rheumatoid arthritis magnetic resonance imaging contrast agent based on folic acid conjugated PEG-b- PAA@SPION.JOURNAL OF MATERIALS CHEMISTRY B,2(19),2938-2946.
MLA Zhong, Yanqi,et al."A rheumatoid arthritis magnetic resonance imaging contrast agent based on folic acid conjugated PEG-b- PAA@SPION".JOURNAL OF MATERIALS CHEMISTRY B 2.19(2014):2938-2946.
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