CAS OpenIR  > 研究所(批量导入)
A novel injectable chlorhexidine thermosensitive hydrogel for periodontal application: preparation, antibacterial activity and toxicity evaluation
Alternative TitleJ. Mater. Sci.-Mater. Med.
Ji, Q. X.; Zhao, Q. S.; Deng, J.; Lu, R.
2010
Conference Name29th Northern Ireland Biomedical Engineering Conference
Source PublicationJournal of Materials Science-Materials in Medicine
Issue8
Pages2435-2442
Conference DateAPR 08, 2009
Conference PlaceQueens Univ Belfast, Belfast, NORTH IRELAND
AbstractThe aim of this paper was to evaluate the application potential of CS-HTCC/GP-0.1%Chx thermosensitive hydrogel which was synthesized using chitosan (CS), quaternized CS, and alpha,beta-glycerophosphate (alpha,beta-GP) loading with 0.1% chlorhexidine (Chx) (w/v) for periodontal treatment. An aqueous solution of CS-HTCC/GP-0.1%Chx was transformed into hydrogel at 6 min when the temperature was increased to 37A degrees C. The scan electron microscopy (SEM) image of the gel was a porous, loose and crosslinked network. In vitro, Chx released over 18 h from the CS-HTCC/GP thermosensitive hydrogel in artificial saliva pH 6.8. Release rate could be controlled through adjustment of alpha,beta-GP or Chx concentration. CS-HTCC/GP-0.1%Chx thermosensitive hydrogel exhibited excellent inhibitory activity against primary periodontal pathogens. CS-HTCC/GP-0.1%Chx thermosensitive hydrogel had no acute toxicity; the maximum tolerated dose in rats was 400 mg/ml. All results indicated that CS-HTCC/GP-0.1%Chx thermosensitive hydrogel is a strong candidate as a local drug delivery system for periodontal treatment.
KeywordSingle-species Biofilm In-vitro Quaternized Chitosan Adult Periodontitis Controlled-release Delivery System Trial Minocycline Gel Gluconate
URL查看原文
Indexed ByISTP
Language英语
Document Type会议论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/11131
Collection研究所(批量导入)
Recommended Citation
GB/T 7714
Ji, Q. X.,Zhao, Q. S.,Deng, J.,et al. A novel injectable chlorhexidine thermosensitive hydrogel for periodontal application: preparation, antibacterial activity and toxicity evaluation[C],2010:2435-2442.
Files in This Item:
File Name/Size DocType Version Access License
20131115-1197-复件 s10(404KB)会议论文 限制开放CC BY-NC-SAApplication Full Text
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Ji, Q. X.]'s Articles
[Zhao, Q. S.]'s Articles
[Deng, J.]'s Articles
Baidu academic
Similar articles in Baidu academic
[Ji, Q. X.]'s Articles
[Zhao, Q. S.]'s Articles
[Deng, J.]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Ji, Q. X.]'s Articles
[Zhao, Q. S.]'s Articles
[Deng, J.]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.