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Preparation of Uniform Microspheres and Microcapsules by Modified Emulsification Process
Alternative TitleMacromol. Symp.
Ma, G. H.; Yang, J.; Lv, P. P.; Wang, L. Y.; Wei, W.; Tian, R.; Wu, J.; Su, Z. G.
2010
Conference Name2nd International Symposium on Advanced Particles/19th Iketani Conference
Source PublicationSymposiaMACROMOLECULAR SYMPOSIA 卷: 288 页: 41-48
Pages41-48
Conference DateAPR 26-29, 2009
Conference PlaceKeio Univ, Yokohama, JAPAN
AbstractUniform microspheres and microcapsules have been prepared by developing a direct membrane emulsification technique from O/W, W/O and W/O/W emulsions in previous studies, and have been applied in bio-separation and drug delivery systems. The diameter can be controlled from several microns to above loo microns. However, smaller microsphere with submicron size, especially from W/O/W emulsion was difficult to be prepared. In this article, a modified emulsification technique was developed to overcome the problem. That is, a pre-emulsion (W/O or W/O/W) with broad size distribution of droplets was prepared firstly by homogenization, sonification or mechanical stirring method, then the pre-emulsion was pressed through the uniform pores of a Shirasu Porous Glass (SPG) membrane to obtain relatively uniform smaller droplets, finally the droplets were solidified to form uniform microsphere or microcapsule. Uniform chitosan microsphere and poly(lactic-glycolic acid) (PLGA) microcapsule with submicron size were prepared from W/O and W/O/W emulsions, respectively. Further more, uniform polymer-magnetite microcapsule was prepared by combining this technique and a new post-precipitation process of magnetite.
KeywordMagnetite Microcapsule Microsphere Modified Membrane Emulsification Technique Uniform Sized Chitosan Microspheres Solvent Evaporation Method Membrane Emulsification Pla Microcapsules Protein Drug Delivery
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Indexed ByISTP
Language英语
Document Type会议论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/11190
Collection研究所(批量导入)
Recommended Citation
GB/T 7714
Ma, G. H.,Yang, J.,Lv, P. P.,et al. Preparation of Uniform Microspheres and Microcapsules by Modified Emulsification Process[C],2010:41-48.
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