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Simulation of protein crystallization on the basis of thermodynamic model
Zhang, X. P.; Zhang, S. J.; Li, C. S.
2003
Conference Name8th International Symposium on Process Systems Engineering
Pages1240-1245
Conference DateJUN 22-27, 2003
Conference PlaceKUNMING, PEOPLES R CHINA
PublisherElsevier Science Bv
AbstractA solid-liquid phase equilibrium thermodynamic model of lysozyme-salt-water system was proposed. UNIQUAC model is applied to calculate the liquid phase activity coefficients. With micro-genetic algorithm, the binary interaction parameters of UNIQUAC model were estimated. The calculated results were agreed well with the experimental data, the average relative deviation was 2.32%. Simulating a protein crystallizer is one of the main tasks for designing and retrofitting a crystallization process. Based on the design task, the simulation of crystallizer was performed considering the thermodynamic model, equipment types and mass material balances. The yield of lysozyme can be obtained. It is meaningful for simulation of protein crystallization process in the industry-scale.
KeywordSimulation Protein Crystallization Thermodynamic Solubility Lysozyme Uniquac Equation Liquid-solid Phase Equilibrium Egg-white Lysozyme Phase-equilibria Solubility Ovalbumin
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Indexed ByISTP
Language英语
Document Type会议论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/11307
Collection研究所(批量导入)
Recommended Citation
GB/T 7714
Zhang, X. P.,Zhang, S. J.,Li, C. S.. Simulation of protein crystallization on the basis of thermodynamic model[C]:Elsevier Science Bv,2003:1240-1245.
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