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The Studies on Pharmacophore Model of K+ Channel Opener
Alternative TitleActa Phys.-Chim. Sin.
Chen Hongming; Zhou Jiaju; Xie Guirong; Pang Suhua
1997
Source PublicationACTA PHYSICO-CHIMICA SINICA
ISSN1000-6818
Volume13Issue:2Pages:101-105
AbstractIn this paper, a set of ATP sensitive K+ channel openers (KCO) whose structure are different, were investigated with the aim to develope our previously defined KCO's pharmacophore model.To validate the effectiveness of the pharmacophore model, A Comparative molecule field analysis (CoMFA) was proceeded, aligning the molecules according to the requirement of the model, and good results were obtained. This pharmacophore model may be a start point to design new KCO compounds.; In this paper, a set of ATP sensitive K+ channel openers (KCO) whose structure are different, were investigated with the aim to develope our previously defined KCO's pharmacophore model.To validate the effectiveness of the pharmacophore model, A Comparative molecule field analysis (CoMFA) was proceeded, aligning the molecules according to the requirement of the model, and good results were obtained. This pharmacophore model may be a start point to design new KCO compounds.
KeywordK++ Channel Opener Comfa Pharmacophore Model Qsar
SubtypeArticle
WOS HeadingsScience & Technology ; Physical Sciences
DOI10.3866/PKU.WHXB19970202
URL查看原文
Indexed BySCI
Language英语
WOS Research AreaChemistry
WOS SubjectChemistry, Physical
WOS IDWOS:000207601200002
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/11346
Collection研究所(批量导入)
AffiliationChinese Acad Sci, Inst Chem Met, Lab Comp Chemostry, Beijing 100080, Peoples R China
Recommended Citation
GB/T 7714
Chen Hongming,Zhou Jiaju,Xie Guirong,et al. The Studies on Pharmacophore Model of K+ Channel Opener[J]. ACTA PHYSICO-CHIMICA SINICA,1997,13(2):101-105.
APA Chen Hongming,Zhou Jiaju,Xie Guirong,&Pang Suhua.(1997).The Studies on Pharmacophore Model of K+ Channel Opener.ACTA PHYSICO-CHIMICA SINICA,13(2),101-105.
MLA Chen Hongming,et al."The Studies on Pharmacophore Model of K+ Channel Opener".ACTA PHYSICO-CHIMICA SINICA 13.2(1997):101-105.
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