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Biotechnological production and applications of microbial phenylalanine ammonia lyase: a recent review
Alternative TitleCrit. Rev. Biotechnol.
Cui, Jian Dong1,2,3; Qiu, Ji Qing4; Fan, Xian Wei5; Jia, Shi Ru3; Tan, Zhi Lei3
2014-09-01
Source PublicationCRITICAL REVIEWS IN BIOTECHNOLOGY
ISSN0738-8551
Volume34Issue:3Pages:258-268
AbstractPhenylalanine ammonia lyase (PAL) catalyzes the nonoxidative deamination of L-phenylalanine to form trans-cinnamic acid and a free ammonium ion. It plays a major role in the catabolism of L-phenylalanine. The presence of PAL has been reported in diverse plants, some fungi, Streptomyces and few Cyanobacteria. In the past two decades, PAL has gained considerable significance in several clinical, industrial and biotechnological applications. Since its discovery, much knowledge has been gathered with reference to the enzyme's importance in phenyl propanoid pathway of plants. In contrast, there is little knowledge about microbial PAL. Furthermore, the commercial source of the enzyme has been mainly obtained from the fungi. This study focuses on the recent advances on the physiological role of microbial PAL and the improvements of PAL biotechnological production both from our laboratory and many others as well as the latest advances on the new applications of microbial PAL.; Phenylalanine ammonia lyase (PAL) catalyzes the nonoxidative deamination of L-phenylalanine to form trans-cinnamic acid and a free ammonium ion. It plays a major role in the catabolism of L-phenylalanine. The presence of PAL has been reported in diverse plants, some fungi, Streptomyces and few Cyanobacteria. In the past two decades, PAL has gained considerable significance in several clinical, industrial and biotechnological applications. Since its discovery, much knowledge has been gathered with reference to the enzyme's importance in phenyl propanoid pathway of plants. In contrast, there is little knowledge about microbial PAL. Furthermore, the commercial source of the enzyme has been mainly obtained from the fungi. This study focuses on the recent advances on the physiological role of microbial PAL and the improvements of PAL biotechnological production both from our laboratory and many others as well as the latest advances on the new applications of microbial PAL.
KeywordActivity Applications Biotechnological Production Microbe Phenylalanine Ammonia Lyase Purification Stability
SubtypeReview
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
DOI10.3109/07388551.2013.791660
URL查看原文
Indexed BySCI
Language英语
WOS KeywordTRANS-CINNAMIC ACID ; P-HYDROXYCINNAMIC ACID ; HIGH-LEVEL EXPRESSION ; RHODOTORULA-GLUTINIS ; RHODOSPORIDIUM-TORULOIDES ; ESCHERICHIA-COLI ; SACCHAROMYCES-CEREVISIAE ; BIOCHEMICAL-CHARACTERIZATION ; SPORIDIOBOLUS-PARAROSEUS ; SUBSTRATE-SPECIFICITY
WOS Research AreaBiotechnology & Applied Microbiology
WOS SubjectBiotechnology & Applied Microbiology
WOS IDWOS:000340769000005
Citation statistics
Cited Times:29[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Version出版稿
Identifierhttp://ir.ipe.ac.cn/handle/122111/11357
Collection研究所(批量导入)
Affiliation1.Hebei Univ Sci & Technol, Res Ctr Fermentat Engn Hebei, Coll Biosci & Bioengn, Shijiazhuang 050018, Peoples R China
2.Chinese Acad Sci, Inst Proc Engn, Natl Key Lab Biochem Engn, Beijing, Peoples R China
3.Tianjin Univ Sci & Technol, Minist Educ, Key Lab Ind Microbiol, Tianjin, Peoples R China
4.Hebei Univ Sci & Technol, Sch Sci, Shijiazhuang, Peoples R China
5.Guangxi Univ, State Key Lab Conservat & Utilizat Subtrop Agrobi, Nanning 530004, Peoples R China
Recommended Citation
GB/T 7714
Cui, Jian Dong,Qiu, Ji Qing,Fan, Xian Wei,et al. Biotechnological production and applications of microbial phenylalanine ammonia lyase: a recent review[J]. CRITICAL REVIEWS IN BIOTECHNOLOGY,2014,34(3):258-268.
APA Cui, Jian Dong,Qiu, Ji Qing,Fan, Xian Wei,Jia, Shi Ru,&Tan, Zhi Lei.(2014).Biotechnological production and applications of microbial phenylalanine ammonia lyase: a recent review.CRITICAL REVIEWS IN BIOTECHNOLOGY,34(3),258-268.
MLA Cui, Jian Dong,et al."Biotechnological production and applications of microbial phenylalanine ammonia lyase: a recent review".CRITICAL REVIEWS IN BIOTECHNOLOGY 34.3(2014):258-268.
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