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Synthesis of 5-tert-butyl-5-(1-hydroxy-2-methylpropyl)-2,2-dimethyl-1,3-dioxane
Alternative TitleChin. J. Org. Chem.
Ju, XL; Xiang, WS; Fan, ZJ
2005-03-01
Source PublicationCHINESE JOURNAL OF ORGANIC CHEMISTRY
ISSN0253-2786
Volume25Issue:3Pages:332-334
AbstractIn order to get the intermediate of 3,4-disubstituted bicyclophosphorothionate of 5-tert-butyl-5(1-hydroxy-2-methylpropyl)-2,2-dimethyl-1,3-dioxane, a method of reacting isopropyl magnesium bromide with 5-tert-butyl-5-formyl-2,2-dimethyl-1,3-dioxane was attempted but failed, since reduction product of the formyl was obtained. The desired compound was achieved by using isopropyl lithium instead of isopropyl magnesium bromide. The yield can be much improved by using an ultrasonic method during the preparation of alkyl lithium.; In order to get the intermediate of 3,4-disubstituted bicyclophosphorothionate of 5-tert-butyl-5(1-hydroxy-2-methylpropyl)-2,2-dimethyl-1,3-dioxane, a method of reacting isopropyl magnesium bromide with 5-tert-butyl-5-formyl-2,2-dimethyl-1,3-dioxane was attempted but failed, since reduction product of the formyl was obtained. The desired compound was achieved by using isopropyl lithium instead of isopropyl magnesium bromide. The yield can be much improved by using an ultrasonic method during the preparation of alkyl lithium.
KeywordIsopropyl Lithium Isopropyl Magnesium Bromide Ultrasonic Irradiation 3 4-disubstituted Bicyclophosphorothionate
SubtypeArticle
WOS HeadingsScience & Technology ; Physical Sciences
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Indexed BySCI
Language英语
WOS KeywordBICYCLIC PHOSPHORUS ESTERS ; PHOSPHATE ESTERS ; CONVULSANTS ; ANTAGONISTS ; TOXICITY
WOS Research AreaChemistry
WOS SubjectChemistry, Organic
WOS IDWOS:000227548000014
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/11418
Collection研究所(批量导入)
Affiliation1.Wuhan Inst Chem Technol, Coll Chem & Pharmaceut Engn, Hebei Key Lab Novel Reactor & Green Chem Technol, Wuhan 430073, Peoples R China
2.Chinese Acad Sci, Inst Proc Engn, Beijing 100080, Peoples R China
3.Nankai Univ, Inst Elementoorgan Chem, State Key Lab Elementoorgan Chem, Tianjin 300071, Peoples R China
Recommended Citation
GB/T 7714
Ju, XL,Xiang, WS,Fan, ZJ. Synthesis of 5-tert-butyl-5-(1-hydroxy-2-methylpropyl)-2,2-dimethyl-1,3-dioxane[J]. CHINESE JOURNAL OF ORGANIC CHEMISTRY,2005,25(3):332-334.
APA Ju, XL,Xiang, WS,&Fan, ZJ.(2005).Synthesis of 5-tert-butyl-5-(1-hydroxy-2-methylpropyl)-2,2-dimethyl-1,3-dioxane.CHINESE JOURNAL OF ORGANIC CHEMISTRY,25(3),332-334.
MLA Ju, XL,et al."Synthesis of 5-tert-butyl-5-(1-hydroxy-2-methylpropyl)-2,2-dimethyl-1,3-dioxane".CHINESE JOURNAL OF ORGANIC CHEMISTRY 25.3(2005):332-334.
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