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Uniform chitosan-coated alginate particles as emulsifiers for preparation of stable Pickering emulsions with stimulus dependence
Alternative TitleColloid Surf. A-Physicochem. Eng. Asp.
Nan, Fangfang1,3; Wu, Jie1; Qi, Feng1,3; Liu, Yan1,3; Ngai, To2; Ma, Guanghui1
2014-08-20
Source PublicationCOLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
ISSN0927-7757
Volume456Issue:8mPages:246-252
AbstractOwing to the absence of surfactants, Pickering emulsion shows little toxicity and emerges as an alternative for preparing potential carriers in biomedical area. Alginate particles are attractive stabilizers for this emulsion owing to their biocompatibility and pH sensitivity. However, their performance is still dissatisfactory due to the difficulty in preparing uniform submicron particles and the inappropriate hydrophilic property. In this study, we developed two strategies to circumvent above shortcomings. Uniform alginate particles with submicron to micron size were successfully prepared by premix membrane emulsification. In addition, the uniform particles were coated with relatively hydrophobic chitosan to overcome the high hydrophilicity of alginate particles. These uniform coated particles effectively stabilized the oil-in-water Pickering emulsion. It was found that the stability of emulsions was tremendously affected by particle size, and the least particle concentrations required for emulsion stability were proportional to the particle radii. Besides the particle size, the pH and salt concentration of aqueous phase was demonstrated to impact the stability of emulsions. The underlying mechanism was discussed in detail, concerning with three different-sized particles. Present work provided an effective strategy to prepare Pickering emulsion, which can be applied to design potent carriers in biomedical area. (C) 2014 Elsevier B.V. All rights reserved.; Owing to the absence of surfactants, Pickering emulsion shows little toxicity and emerges as an alternative for preparing potential carriers in biomedical area. Alginate particles are attractive stabilizers for this emulsion owing to their biocompatibility and pH sensitivity. However, their performance is still dissatisfactory due to the difficulty in preparing uniform submicron particles and the inappropriate hydrophilic property. In this study, we developed two strategies to circumvent above shortcomings. Uniform alginate particles with submicron to micron size were successfully prepared by premix membrane emulsification. In addition, the uniform particles were coated with relatively hydrophobic chitosan to overcome the high hydrophilicity of alginate particles. These uniform coated particles effectively stabilized the oil-in-water Pickering emulsion. It was found that the stability of emulsions was tremendously affected by particle size, and the least particle concentrations required for emulsion stability were proportional to the particle radii. Besides the particle size, the pH and salt concentration of aqueous phase was demonstrated to impact the stability of emulsions. The underlying mechanism was discussed in detail, concerning with three different-sized particles. Present work provided an effective strategy to prepare Pickering emulsion, which can be applied to design potent carriers in biomedical area. (C) 2014 Elsevier B.V. All rights reserved.
KeywordPickering Emulsion Alginate Chitosan Uniform-sized Stimulus Dependent
SubtypeArticle
WOS HeadingsScience & Technology ; Physical Sciences
DOI10.1016/j.colsurfa.2014.05.017
URL查看原文
Indexed BySCI
Language英语
WOS KeywordMICROGEL PARTICLES ; DRUG-DELIVERY ; COLLOIDOSOMES ; NANOPARTICLES ; PH ; EMULSIFICATION ; MICROCAPSULES ; MICROSPHERES ; ACID
WOS Research AreaChemistry
WOS SubjectChemistry, Physical
WOS IDWOS:000340318000032
Citation statistics
Cited Times:47[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Version出版稿
Identifierhttp://ir.ipe.ac.cn/handle/122111/11500
Collection研究所(批量导入)
Affiliation1.Chinese Acad Sci, Inst Proc Engn, Key Lab Biopharmaceut Prod & Formulat Engn, Natl Key Lab Biochem Engn, Beijing 100190, Peoples R China
2.Chinese Univ Hong Kong, Dept Chem, Shatin, Hong Kong, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Nan, Fangfang,Wu, Jie,Qi, Feng,et al. Uniform chitosan-coated alginate particles as emulsifiers for preparation of stable Pickering emulsions with stimulus dependence[J]. COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS,2014,456(8m):246-252.
APA Nan, Fangfang,Wu, Jie,Qi, Feng,Liu, Yan,Ngai, To,&Ma, Guanghui.(2014).Uniform chitosan-coated alginate particles as emulsifiers for preparation of stable Pickering emulsions with stimulus dependence.COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS,456(8m),246-252.
MLA Nan, Fangfang,et al."Uniform chitosan-coated alginate particles as emulsifiers for preparation of stable Pickering emulsions with stimulus dependence".COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS 456.8m(2014):246-252.
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