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Thermo-triggered drug delivery from polymeric micelles of poly(N-isopropylacrylamide-co-acrylamide)-b-poly(n-butyl methacrylate) for tumor targeting
Alternative TitleJ. Bioact. Compat. Polym.
Sun, Feilong1,2; Wang, Yuxia1; Wei, Yi1; Cheng, Gang2; Ma, Guanghui1
2014-07-01
Source PublicationJOURNAL OF BIOACTIVE AND COMPATIBLE POLYMERS
ISSN0883-9115
Volume29Issue:4Pages:301-317
AbstractNovel temperature-sensitive micelles, possessing a core-shell structure, were successfully fabricated and evaluated as possible systems for targeting anticancer drugs to solid tumors. The amphiphilic block copolymer poly(N-isopropylacrylamide-co-acrylamide)-b-poly(n-butyl methacrylate) was used to achieve a stimuli-responsive on/off release and spatial specificity. The anticancer drug methotrexate, which is poorly water soluble, was used as the model. Fourier transform-infrared spectroscopy, proton nuclear magnetic resonance spectroscopy, gel-permeation chromatography, and critical micelle concentration were used to evaluate the successful synthesis of block copolymers with a lower critical solution temperature similar to 40 degrees C. Based on transmission electron microscope images, the micelles are spherical particles with narrow size distribution. The thermally triggered release of methotrexate was observed in vitro. Quartz crystal microbalance with dissipation was used to investigate the interactions of the polymeric micelles with bovine serum albumin, to illustrate protein adsorption and cell attachment. Cytotoxicity studies were conducted on Lewis lung carcinoma cells, and the anticancer activity of methotrexate-loaded micelles was significantly enhanced in combination with hyperthermia. The thermo-sensitive characteristics of the micelles make them applicable as smart drug delivery systems, when combined with localized hyperthermia.; Novel temperature-sensitive micelles, possessing a core-shell structure, were successfully fabricated and evaluated as possible systems for targeting anticancer drugs to solid tumors. The amphiphilic block copolymer poly(N-isopropylacrylamide-co-acrylamide)-b-poly(n-butyl methacrylate) was used to achieve a stimuli-responsive on/off release and spatial specificity. The anticancer drug methotrexate, which is poorly water soluble, was used as the model. Fourier transform-infrared spectroscopy, proton nuclear magnetic resonance spectroscopy, gel-permeation chromatography, and critical micelle concentration were used to evaluate the successful synthesis of block copolymers with a lower critical solution temperature similar to 40 degrees C. Based on transmission electron microscope images, the micelles are spherical particles with narrow size distribution. The thermally triggered release of methotrexate was observed in vitro. Quartz crystal microbalance with dissipation was used to investigate the interactions of the polymeric micelles with bovine serum albumin, to illustrate protein adsorption and cell attachment. Cytotoxicity studies were conducted on Lewis lung carcinoma cells, and the anticancer activity of methotrexate-loaded micelles was significantly enhanced in combination with hyperthermia. The thermo-sensitive characteristics of the micelles make them applicable as smart drug delivery systems, when combined with localized hyperthermia.
KeywordBlock Copolymer Micelle Thermo-sensitive Controlled Drug Release Tumor Targeting Hyperthermia Thermo-triggered Drug Delivery
SubtypeArticle
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine ; Technology ; Physical Sciences
DOI10.1177/0883911514535288
URL查看原文
Indexed BySCI
Language英语
WOS KeywordCORE-SHELL NANOPARTICLES ; IN-VITRO RELEASE ; BLOCK-COPOLYMER ; THERMORESPONSIVE MICELLES ; CELLULAR UPTAKE ; STAR BLOCK ; DOXORUBICIN ; SURFACES ; CELLS ; MICELLIZATION
WOS Research AreaBiotechnology & Applied Microbiology ; Materials Science ; Polymer Science
WOS SubjectBiotechnology & Applied Microbiology ; Materials Science, Biomaterials ; Polymer Science
WOS IDWOS:000340132800001
Citation statistics
Cited Times:15[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Version出版稿
Identifierhttp://ir.ipe.ac.cn/handle/122111/11518
Collection研究所(批量导入)
Affiliation1.Chinese Acad Sci, Inst Proc Engn, Natl Key Lab Biochem Engn, Beijing 100190, Peoples R China
2.Shenyang Pharmaceut Univ, Dept Pharmaceut, Shenyang, Peoples R China
Recommended Citation
GB/T 7714
Sun, Feilong,Wang, Yuxia,Wei, Yi,et al. Thermo-triggered drug delivery from polymeric micelles of poly(N-isopropylacrylamide-co-acrylamide)-b-poly(n-butyl methacrylate) for tumor targeting[J]. JOURNAL OF BIOACTIVE AND COMPATIBLE POLYMERS,2014,29(4):301-317.
APA Sun, Feilong,Wang, Yuxia,Wei, Yi,Cheng, Gang,&Ma, Guanghui.(2014).Thermo-triggered drug delivery from polymeric micelles of poly(N-isopropylacrylamide-co-acrylamide)-b-poly(n-butyl methacrylate) for tumor targeting.JOURNAL OF BIOACTIVE AND COMPATIBLE POLYMERS,29(4),301-317.
MLA Sun, Feilong,et al."Thermo-triggered drug delivery from polymeric micelles of poly(N-isopropylacrylamide-co-acrylamide)-b-poly(n-butyl methacrylate) for tumor targeting".JOURNAL OF BIOACTIVE AND COMPATIBLE POLYMERS 29.4(2014):301-317.
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