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Improving the lactic acid production of Actinobacillus succinogenes by using a novel fermentation and separation integration system
Alternative TitleProcess Biochem.
Wang, Caixia1,2; Li, Qiang1; Wang, Dan3; Xing, Jianmin1
2014-08-01
Source PublicationPROCESS BIOCHEMISTRY
ISSN1359-5113
Volume49Issue:8Pages:1245-1250
AbstractThis work describes the development of a novel integrated system for lactic acid production by Actinobacillus succinogenes. Fermentation and separation were integrated with the use of a microfiltration (MF) membrane, and lactic acid was recovered by resin adsorption following MF. The fermentation broth containing residual sugar and nutrients was then recycled back into the fermenter after lactic acid adsorption. This novel approach overcame the problem of product inhibition and extended the cell growth period from 41 h to 120 h. Production of lactic acid was improved by 23% to 183.4 g L-1. The overall yield and productivity for glucose were 0.97 g g(-1) and 1.53 g L-1 h(-1), respectively. These experimental results indicate that the integrated system could benefit continuous production of lactic acid at high levels. (C) 2014 Elsevier Ltd. All rights reserved.; This work describes the development of a novel integrated system for lactic acid production by Actinobacillus succinogenes. Fermentation and separation were integrated with the use of a microfiltration (MF) membrane, and lactic acid was recovered by resin adsorption following MF. The fermentation broth containing residual sugar and nutrients was then recycled back into the fermenter after lactic acid adsorption. This novel approach overcame the problem of product inhibition and extended the cell growth period from 41 h to 120 h. Production of lactic acid was improved by 23% to 183.4 g L-1. The overall yield and productivity for glucose were 0.97 g g(-1) and 1.53 g L-1 h(-1), respectively. These experimental results indicate that the integrated system could benefit continuous production of lactic acid at high levels. (C) 2014 Elsevier Ltd. All rights reserved.
KeywordLactic Acid Actinobacillus Succinogenes Membrane Filtration Adsorptive Separation Process Integration
SubtypeArticle
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine ; Technology
DOI10.1016/j.procbio.2014.04.009
URL查看原文
Indexed BySCI
Language英语
WOS KeywordSUCCINIC-ACID ; BROTH ; PURIFICATION ; BIOREACTOR ; ADSORPTION ; XYLOSE ; YIELD
WOS Research AreaBiochemistry & Molecular Biology ; Biotechnology & Applied Microbiology ; Engineering
WOS SubjectBiochemistry & Molecular Biology ; Biotechnology & Applied Microbiology ; Engineering, Chemical
WOS IDWOS:000340331900005
Citation statistics
Cited Times:15[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Version出版稿
Identifierhttp://ir.ipe.ac.cn/handle/122111/11529
Collection研究所(批量导入)
Affiliation1.Chinese Acad Sci, Inst Proc Engn, Natl Key Lab Biochem Engn, Beijing 100190, Peoples R China
2.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China
3.Chongqing Univ, Coll Chem & Chem Engn, Chongqing 400044, Peoples R China
Recommended Citation
GB/T 7714
Wang, Caixia,Li, Qiang,Wang, Dan,et al. Improving the lactic acid production of Actinobacillus succinogenes by using a novel fermentation and separation integration system[J]. PROCESS BIOCHEMISTRY,2014,49(8):1245-1250.
APA Wang, Caixia,Li, Qiang,Wang, Dan,&Xing, Jianmin.(2014).Improving the lactic acid production of Actinobacillus succinogenes by using a novel fermentation and separation integration system.PROCESS BIOCHEMISTRY,49(8),1245-1250.
MLA Wang, Caixia,et al."Improving the lactic acid production of Actinobacillus succinogenes by using a novel fermentation and separation integration system".PROCESS BIOCHEMISTRY 49.8(2014):1245-1250.
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