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Cellulose-graft-poly(L-lactic acid) nanoparticles for efficient delivery of anti-cancer drugs
Alternative TitleJ. Mat. Chem. B
Dai, Lin1; Yang, Tingyuan2; He, Jing1; Deng, Lihong1; Liu, Jing1; Wang, Luying1; Lei, Jiandu1; Wang, Lianyan2
2014-10-21
Source PublicationJOURNAL OF MATERIALS CHEMISTRY B
ISSN2050-750X
Volume2Issue:39Pages:6749-6757
AbstractCellulose based carriers have the potential for sustained release of drugs, which can protect drugs and deliver them to the target site. Herein, BA-loaded cellulose-graft-poly(L-lactic acid) nanoparticles (CE-g-PLLA/BA NPs) were fabricated by employing cellulose (CE) and poly(L-lactic acid) (PLLA) as materials and betulinic acid (BA) as a model drug. Both drug-free and BA-loaded nanoparticles were spherical in shape with a uniform size of 100-170 nm. The release of BA from CE-g-PLLA/BA NPs was relatively slow. In vitro cytotoxicity studies with A549 and LLC cell lines suggested that CE-g-PLLA/BA NPs were slightly superior to BA in antitumor activity and CE-g-PLLA NPs were non-toxic. The antitumor effect of the CE-g-PLLA/BA NPs in a mouse tumor xenograft model exhibited much better tumor inhibition efficacy and fewer side effects than that of BA, strongly supporting their use as efficient carriers for anti-cancer therapy.; Cellulose based carriers have the potential for sustained release of drugs, which can protect drugs and deliver them to the target site. Herein, BA-loaded cellulose-graft-poly(L-lactic acid) nanoparticles (CE-g-PLLA/BA NPs) were fabricated by employing cellulose (CE) and poly(L-lactic acid) (PLLA) as materials and betulinic acid (BA) as a model drug. Both drug-free and BA-loaded nanoparticles were spherical in shape with a uniform size of 100-170 nm. The release of BA from CE-g-PLLA/BA NPs was relatively slow. In vitro cytotoxicity studies with A549 and LLC cell lines suggested that CE-g-PLLA/BA NPs were slightly superior to BA in antitumor activity and CE-g-PLLA NPs were non-toxic. The antitumor effect of the CE-g-PLLA/BA NPs in a mouse tumor xenograft model exhibited much better tumor inhibition efficacy and fewer side effects than that of BA, strongly supporting their use as efficient carriers for anti-cancer therapy.
KeywordBetulinic Acid Macromolecular Therapeutics Carbon Nanotubes Human-melanoma Cellulose Cancer Cytotoxicity Cells Carboxymethylcellulose Degradation
SubtypeArticle
WOS HeadingsScience & Technology ; Technology
DOI10.1039/c4tb00956h
URL查看原文
Indexed BySCI
Language英语
WOS KeywordBETULINIC ACID ; MACROMOLECULAR THERAPEUTICS ; CARBON NANOTUBES ; HUMAN-MELANOMA ; CELLULOSE ; CANCER ; CYTOTOXICITY ; CELLS ; CARBOXYMETHYLCELLULOSE ; DEGRADATION
WOS Research AreaMaterials Science
WOS SubjectMaterials Science, Biomaterials
WOS IDWOS:000342856400008
Citation statistics
Cited Times:29[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/11672
Collection研究所(批量导入)
Affiliation1.Beijing Forestry Univ, MOE Key Lab Wooden Mat Sci & Applicat, Beijing 100083, Peoples R China
2.Chinese Acad Sci, Inst Proc Engn, Natl Key Lab Biochem Engn, Beijing 100190, Peoples R China
Recommended Citation
GB/T 7714
Dai, Lin,Yang, Tingyuan,He, Jing,et al. Cellulose-graft-poly(L-lactic acid) nanoparticles for efficient delivery of anti-cancer drugs[J]. JOURNAL OF MATERIALS CHEMISTRY B,2014,2(39):6749-6757.
APA Dai, Lin.,Yang, Tingyuan.,He, Jing.,Deng, Lihong.,Liu, Jing.,...&Wang, Lianyan.(2014).Cellulose-graft-poly(L-lactic acid) nanoparticles for efficient delivery of anti-cancer drugs.JOURNAL OF MATERIALS CHEMISTRY B,2(39),6749-6757.
MLA Dai, Lin,et al."Cellulose-graft-poly(L-lactic acid) nanoparticles for efficient delivery of anti-cancer drugs".JOURNAL OF MATERIALS CHEMISTRY B 2.39(2014):6749-6757.
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