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Preparation of uniform-sized colloidosomes based on chitosan-coated alginate particles and its application for oral insulin delivery
Alternative TitleJ. Mat. Chem. B
Nan, Fangfang1,3; Wu, Jie1; Qi, Feng1,3; Fan, Qingze1,3; Ma, Guanghui1; Ngai, To2
2014
Source PublicationJOURNAL OF MATERIALS CHEMISTRY B
ISSN2050-750X
Volume2Issue:42Pages:7403-7409
AbstractColloidosomes are microcapsules that consist of a hollow core coated by a shell composed of self-assembled colloidal particles. In recent years, they have attracted significant attention as potential vehicles for the controlled delivery of active ingredients. A key challenge in such applications is the production of uniform-sized colloidosomes for the encapsulation of active ingredients such that the actual delivery amount can be well controlled. Based on our previous study on an ethyl acetate-in-water emulsion stabilized by chitosan-coated alginate particles, we further prepared monodisperse colloidosomes with a high yield and low permeability by combining the premix membrane emulsification technique and polymer deposition method. The potential application of the formed colloidosomes as oral insulin delivery vehicles was investigated. Our results revealed that in comparison to conventional PLGA microspheres, the formulated colloidosomes showed high drug encapsulation efficiency (up to 96.7%) and an obvious pH sensitive release profile. Moreover, in animal testing, the colloidosomes formulation achieved a long-term hypoglycemic effect up to 6 h, which confirmed its application as an oral drug delivery system.; Colloidosomes are microcapsules that consist of a hollow core coated by a shell composed of self-assembled colloidal particles. In recent years, they have attracted significant attention as potential vehicles for the controlled delivery of active ingredients. A key challenge in such applications is the production of uniform-sized colloidosomes for the encapsulation of active ingredients such that the actual delivery amount can be well controlled. Based on our previous study on an ethyl acetate-in-water emulsion stabilized by chitosan-coated alginate particles, we further prepared monodisperse colloidosomes with a high yield and low permeability by combining the premix membrane emulsification technique and polymer deposition method. The potential application of the formed colloidosomes as oral insulin delivery vehicles was investigated. Our results revealed that in comparison to conventional PLGA microspheres, the formulated colloidosomes showed high drug encapsulation efficiency (up to 96.7%) and an obvious pH sensitive release profile. Moreover, in animal testing, the colloidosomes formulation achieved a long-term hypoglycemic effect up to 6 h, which confirmed its application as an oral drug delivery system.
KeywordPremix Membrane Emulsification Nanoparticle Colloidosomes Multiple Emulsions Microcapsules Liposomes Release
SubtypeArticle
WOS HeadingsScience & Technology ; Technology
DOI10.1039/c4tb01259c
URL查看原文
Indexed BySCI
Language英语
WOS KeywordPREMIX MEMBRANE EMULSIFICATION ; NANOPARTICLE COLLOIDOSOMES ; MULTIPLE EMULSIONS ; MICROCAPSULES ; LIPOSOMES ; RELEASE
WOS Research AreaMaterials Science
WOS SubjectMaterials Science, Biomaterials
WOS IDWOS:000343038600013
Citation statistics
Cited Times:21[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/11683
Collection研究所(批量导入)
Affiliation1.Chinese Acad Sci, Inst Proc Engn, Key Lab Biopharmaceut Prod & Formulat Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China
2.Chinese Univ Hong Kong, Dept Chem, Shatin, Hong Kong, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Nan, Fangfang,Wu, Jie,Qi, Feng,et al. Preparation of uniform-sized colloidosomes based on chitosan-coated alginate particles and its application for oral insulin delivery[J]. JOURNAL OF MATERIALS CHEMISTRY B,2014,2(42):7403-7409.
APA Nan, Fangfang,Wu, Jie,Qi, Feng,Fan, Qingze,Ma, Guanghui,&Ngai, To.(2014).Preparation of uniform-sized colloidosomes based on chitosan-coated alginate particles and its application for oral insulin delivery.JOURNAL OF MATERIALS CHEMISTRY B,2(42),7403-7409.
MLA Nan, Fangfang,et al."Preparation of uniform-sized colloidosomes based on chitosan-coated alginate particles and its application for oral insulin delivery".JOURNAL OF MATERIALS CHEMISTRY B 2.42(2014):7403-7409.
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