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Self-assembled serum albumin-poly(L-lactic acid) nanoparticles: a novel nanoparticle platform for drug delivery in cancer
Alternative TitleRSC Adv.
Dai, Lin1; Li, Chun-Xiao1; Liu, Ke-Feng1; Su, Hai-Jia2; Chen, Bi-Qiang2; Zhang, Gui-Feng3; He, Jing1; Lei, Jian-Du1
2015
Source PublicationRSC ADVANCES
ISSN2046-2069
Volume5Issue:20Pages:15612-15620
Abstract

We developed a new self-assembled bovine serum albumin-poly(L-lactic acid) nanoparticle platform for anticancer drug delivery made from a bovine serum albumin-poly(L-lactic acid) polymer conjugate. Depending on the ratio of bovine serum albumin (BSA) to poly(L-lactic acid) (PLLA), these conjugates self-assemble into uniform spherical nanoparticles with different sizes. Then, BA-loaded BSA-PLLA nanoparticles (BSA-PLLA/BA NPs) were prepared by using BSA-PLLA conjugates as prototype materials, and betulinic acid (BA) as a model drug. In vitro cytotoxicity studies with human lung cancer cell lines (A549) and murine Lewis lung carcinoma (LLC) cell lines suggested that the BSA-PLLA/BA NPs were significantly superior to the model drug BA in antitumor activity and the BSA-PLLA NPs were non-toxic. Compared to free BA, the BSA-PLLA/BA NPs provided significantly higher blood circulation half-time of free BA (5.02-fold). The antitumor effect of the BSA-PLLA/BA NPs in a mouse tumor xenograft model showed much better tumor inhibition efficacy and fewer side effects than that of free BA. It may be attributed to the preferential tumor accumulation and increases the solubility of the drug in water, strongly supporting their use as high-performance carriers for anti-cancer therapy.

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We developed a new self-assembled bovine serum albumin-poly(L-lactic acid) nanoparticle platform for anticancer drug delivery made from a bovine serum albumin-poly(L-lactic acid) polymer conjugate. Depending on the ratio of bovine serum albumin (BSA) to poly(L-lactic acid) (PLLA), these conjugates self-assemble into uniform spherical nanoparticles with different sizes. Then, BA-loaded BSA-PLLA nanoparticles (BSA-PLLA/BA NPs) were prepared by using BSA-PLLA conjugates as prototype materials, and betulinic acid (BA) as a model drug. In vitro cytotoxicity studies with human lung cancer cell lines (A549) and murine Lewis lung carcinoma (LLC) cell lines suggested that the BSA-PLLA/BA NPs were significantly superior to the model drug BA in antitumor activity and the BSA-PLLA NPs were non-toxic. Compared to free BA, the BSA-PLLA/BA NPs provided significantly higher blood circulation half-time of free BA (5.02-fold). The antitumor effect of the BSA-PLLA/BA NPs in a mouse tumor xenograft model showed much better tumor inhibition efficacy and fewer side effects than that of free BA. It may be attributed to the preferential tumor accumulation and increases the solubility of the drug in water, strongly supporting their use as high-performance carriers for anti-cancer therapy.

KeywordBetulinic Acid Macromolecular Therapeutics Viral Nanoparticles Micelle Formation Carbon Nanotubes Aqueous-media Cytotoxicity Nanocarriers Cells Chemotherapy
SubtypeArticle
WOS HeadingsScience & Technology ; Physical Sciences
DOI10.1039/c4ra16346j
URL查看原文
Indexed BySCI
Language英语
WOS KeywordBETULINIC ACID ; MACROMOLECULAR THERAPEUTICS ; VIRAL NANOPARTICLES ; MICELLE FORMATION ; CARBON NANOTUBES ; AQUEOUS-MEDIA ; CYTOTOXICITY ; NANOCARRIERS ; CELLS ; CHEMOTHERAPY
WOS Research AreaChemistry
WOS SubjectChemistry, Multidisciplinary
WOS IDWOS:000349435000082
Citation statistics
Cited Times:21[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/11720
Collection研究所(批量导入)
Affiliation1.Beijing Forestry Univ, Beijing Key Lab Lignocellulos Chem, Beijing 100083, Peoples R China
2.Beijing Univ Chem Technol, Beijing Key Lab Bioproc, Beijing 100029, Peoples R China
3.Chinese Acad Sci, Inst Proc Engn, Beijing 100090, Peoples R China
Recommended Citation
GB/T 7714
Dai, Lin,Li, Chun-Xiao,Liu, Ke-Feng,et al. Self-assembled serum albumin-poly(L-lactic acid) nanoparticles: a novel nanoparticle platform for drug delivery in cancer[J]. RSC ADVANCES,2015,5(20):15612-15620.
APA Dai, Lin.,Li, Chun-Xiao.,Liu, Ke-Feng.,Su, Hai-Jia.,Chen, Bi-Qiang.,...&Lei, Jian-Du.(2015).Self-assembled serum albumin-poly(L-lactic acid) nanoparticles: a novel nanoparticle platform for drug delivery in cancer.RSC ADVANCES,5(20),15612-15620.
MLA Dai, Lin,et al."Self-assembled serum albumin-poly(L-lactic acid) nanoparticles: a novel nanoparticle platform for drug delivery in cancer".RSC ADVANCES 5.20(2015):15612-15620.
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