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Programmed co-delivery of paclitaxel and doxorubicin boosted by camouflaging with erythrocyte membrane
Alternative TitleNanoscale
Fu, Qiang1,2; Lv, Piping1; Chen, Zhongke2; Ni, Dezhi1; Zhang, Lijun1; Yue, Hua1; Yue, Zhanguo1; Wei, Wei1; Ma, Guanghui1,3
2015
Source PublicationNANOSCALE
ISSN2040-3364
Volume7Issue:9Pages:4020-4030
Abstract

Combination chemotherapy has been proven promising for cancer treatment, but unsatisfactory therapeutic data and increased side effects slow down the development in the clinic. In this study, we develop an effective approach to co-encapsulate a hydrophilic-hydrophobic chemotherapeutic drug pair (paclitaxel and doxorubicin) into magnetic O-carboxymethyl-chitosan nanoparticles. To endow them with the ability of programmed delivery, these carriers are further camouflaged with an Arg-Gly-Asp anchored erythrocyte membrane. Compared with the traditional polyethylene glycol coating method, this biomimetic decoration strategy is demonstrated to be superior in prolonging circulation time, improving tumor accumulation, facilitating tumor uptake, and tuning intracellular fate. These outstanding properties enable the as-designed nanodevice to exhibit greater tumor growth inhibition ability and much lower side effects than the combined use of commercial formulations.

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Combination chemotherapy has been proven promising for cancer treatment, but unsatisfactory therapeutic data and increased side effects slow down the development in the clinic. In this study, we develop an effective approach to co-encapsulate a hydrophilic-hydrophobic chemotherapeutic drug pair (paclitaxel and doxorubicin) into magnetic O-carboxymethyl-chitosan nanoparticles. To endow them with the ability of programmed delivery, these carriers are further camouflaged with an Arg-Gly-Asp anchored erythrocyte membrane. Compared with the traditional polyethylene glycol coating method, this biomimetic decoration strategy is demonstrated to be superior in prolonging circulation time, improving tumor accumulation, facilitating tumor uptake, and tuning intracellular fate. These outstanding properties enable the as-designed nanodevice to exhibit greater tumor growth inhibition ability and much lower side effects than the combined use of commercial formulations.

KeywordPolymeric Nanoparticles Chitosan Nanoparticles Combination Therapy Pancreatic-cancer Drug-resistance Lung-cancer Chemotherapy Sirna Nanocarriers Efficacy
SubtypeArticle
WOS HeadingsScience & Technology ; Physical Sciences ; Technology
DOI10.1039/c4nr07027e
URL查看原文
Indexed BySCI
Language英语
WOS KeywordPOLYMERIC NANOPARTICLES ; CHITOSAN NANOPARTICLES ; COMBINATION THERAPY ; PANCREATIC-CANCER ; DRUG-RESISTANCE ; LUNG-CANCER ; CHEMOTHERAPY ; SIRNA ; NANOCARRIERS ; EFFICACY
WOS Research AreaChemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
WOS SubjectChemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied
WOS IDWOS:000350143700025
Citation statistics
Cited Times:60[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/11730
Collection研究所(批量导入)
Affiliation1.Chinese Acad Sci, Inst Proc Engn, Natl Key Lab Biochem Engn, Beijing 100190, Peoples R China
2.Shandong Univ, Life Sci Coll, Key Lab Cell & Dev Biol, Jinan 250100, Peoples R China
3.Collaborat Innovat Ctr Chem Sci & Engn Tianjin, Tianjin 300072, Peoples R China
Recommended Citation
GB/T 7714
Fu, Qiang,Lv, Piping,Chen, Zhongke,et al. Programmed co-delivery of paclitaxel and doxorubicin boosted by camouflaging with erythrocyte membrane[J]. NANOSCALE,2015,7(9):4020-4030.
APA Fu, Qiang.,Lv, Piping.,Chen, Zhongke.,Ni, Dezhi.,Zhang, Lijun.,...&Ma, Guanghui.(2015).Programmed co-delivery of paclitaxel and doxorubicin boosted by camouflaging with erythrocyte membrane.NANOSCALE,7(9),4020-4030.
MLA Fu, Qiang,et al."Programmed co-delivery of paclitaxel and doxorubicin boosted by camouflaging with erythrocyte membrane".NANOSCALE 7.9(2015):4020-4030.
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