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Programmed co-delivery of paclitaxel and doxorubicin boosted by camouflaging with erythrocyte membrane | |
Alternative Title | Nanoscale |
Fu, Qiang1,2; Lv, Piping1; Chen, Zhongke2; Ni, Dezhi1; Zhang, Lijun1; Yue, Hua1; Yue, Zhanguo1; Wei, Wei1; Ma, Guanghui1,3 | |
2015 | |
Source Publication | NANOSCALE
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ISSN | 2040-3364 |
Volume | 7Issue:9Pages:4020-4030 |
Abstract | Combination chemotherapy has been proven promising for cancer treatment, but unsatisfactory therapeutic data and increased side effects slow down the development in the clinic. In this study, we develop an effective approach to co-encapsulate a hydrophilic-hydrophobic chemotherapeutic drug pair (paclitaxel and doxorubicin) into magnetic O-carboxymethyl-chitosan nanoparticles. To endow them with the ability of programmed delivery, these carriers are further camouflaged with an Arg-Gly-Asp anchored erythrocyte membrane. Compared with the traditional polyethylene glycol coating method, this biomimetic decoration strategy is demonstrated to be superior in prolonging circulation time, improving tumor accumulation, facilitating tumor uptake, and tuning intracellular fate. These outstanding properties enable the as-designed nanodevice to exhibit greater tumor growth inhibition ability and much lower side effects than the combined use of commercial formulations. ;Combination chemotherapy has been proven promising for cancer treatment, but unsatisfactory therapeutic data and increased side effects slow down the development in the clinic. In this study, we develop an effective approach to co-encapsulate a hydrophilic-hydrophobic chemotherapeutic drug pair (paclitaxel and doxorubicin) into magnetic O-carboxymethyl-chitosan nanoparticles. To endow them with the ability of programmed delivery, these carriers are further camouflaged with an Arg-Gly-Asp anchored erythrocyte membrane. Compared with the traditional polyethylene glycol coating method, this biomimetic decoration strategy is demonstrated to be superior in prolonging circulation time, improving tumor accumulation, facilitating tumor uptake, and tuning intracellular fate. These outstanding properties enable the as-designed nanodevice to exhibit greater tumor growth inhibition ability and much lower side effects than the combined use of commercial formulations. |
Keyword | Polymeric Nanoparticles Chitosan Nanoparticles Combination Therapy Pancreatic-cancer Drug-resistance Lung-cancer Chemotherapy Sirna Nanocarriers Efficacy |
Subtype | Article |
WOS Headings | Science & Technology ; Physical Sciences ; Technology |
DOI | 10.1039/c4nr07027e |
URL | 查看原文 |
Indexed By | SCI |
Language | 英语 |
WOS Keyword | POLYMERIC NANOPARTICLES ; CHITOSAN NANOPARTICLES ; COMBINATION THERAPY ; PANCREATIC-CANCER ; DRUG-RESISTANCE ; LUNG-CANCER ; CHEMOTHERAPY ; SIRNA ; NANOCARRIERS ; EFFICACY |
WOS Research Area | Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics |
WOS Subject | Chemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied |
WOS ID | WOS:000350143700025 |
Citation statistics | |
Document Type | 期刊论文 |
Identifier | http://ir.ipe.ac.cn/handle/122111/11730 |
Collection | 研究所(批量导入) |
Affiliation | 1.Chinese Acad Sci, Inst Proc Engn, Natl Key Lab Biochem Engn, Beijing 100190, Peoples R China 2.Shandong Univ, Life Sci Coll, Key Lab Cell & Dev Biol, Jinan 250100, Peoples R China 3.Collaborat Innovat Ctr Chem Sci & Engn Tianjin, Tianjin 300072, Peoples R China |
Recommended Citation GB/T 7714 | Fu, Qiang,Lv, Piping,Chen, Zhongke,et al. Programmed co-delivery of paclitaxel and doxorubicin boosted by camouflaging with erythrocyte membrane[J]. NANOSCALE,2015,7(9):4020-4030. |
APA | Fu, Qiang.,Lv, Piping.,Chen, Zhongke.,Ni, Dezhi.,Zhang, Lijun.,...&Ma, Guanghui.(2015).Programmed co-delivery of paclitaxel and doxorubicin boosted by camouflaging with erythrocyte membrane.NANOSCALE,7(9),4020-4030. |
MLA | Fu, Qiang,et al."Programmed co-delivery of paclitaxel and doxorubicin boosted by camouflaging with erythrocyte membrane".NANOSCALE 7.9(2015):4020-4030. |
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Programmed co-delive(10328KB) | 期刊论文 | 出版稿 | 限制开放 | CC BY-NC-SA | Application Full Text |
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