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Hypoglycemic activity and acute oral toxicity of chromium methionine. complexes in mice
Alternative TitleJ. Trace Elem. Med. Biol.
Tang, H. Y.; Xiao, Q. G.; Xu, H. B.; Zhang, Y.
2015
Source PublicationJournal of Trace Elements in Medicine and Biology
Issue0Pages:136-144
Abstract

The hypoglycemic activity of chromium methionine (CrMet) in alloxan-induced diabetic (AID) mice was investigated and compared with those of chromium trichloride hexahydrate (CrCl3 center dot 6H(2)O) and chromium nicotinate (CrNic) through a 15-day feeding experiment. The acute oral toxicity of CrMet was also investigated in ICR (Institute for Cancer Research) mice by a single oral gavage. The anti-diabetic activity of CrMet was explored in detail from the aspects of body weight (BW), blood glucose, triglyceride, total cholesterol, liver glycogen levels, aspartate transaminase (AST) and alanine transaminase (ALT) levels. The obtained results showed that CrMet had beneficial effects on glucose and lipid metabolism, and might possess hepatoprotective efficacy for diabetes. Daily treatment with 500 and 1000 mu g Cr/kg BW of CrMet in AID mice for 15 days indicated that this low-molecular-weight organic chromium complex had better bioavailability and more beneficial effects on diabetics than CrCl3 center dot 6H(2)O. CrMet also had advantage over CrNic in the control of AST and ALT activities. Acute toxicity studies revealed that CrMet had low toxicity potential and relatively high safety margins in mice with the LD50 value higher than 10.0 g/kg BW. These findings suggest that CrMet might be of potential value in the therapy and protection of diabetes. (C) 2014 Elsevier GmbH. All rights reserved.

KeywordChromium Methionine Hypoglycemic Activity Acute Oral Toxicity Mice Periparturient Dairy-cows Induced Diabetic-rats Lead-exposed Rats Dietary Chromium Supplemental Chromium Heat-stress Picolinate Supplementation Drosophila-melanogaster Metabolic Parameters Growth-performance
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Indexed BySCI
Language英语
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/11830
Collection研究所(批量导入)
Recommended Citation
GB/T 7714
Tang, H. Y.,Xiao, Q. G.,Xu, H. B.,et al. Hypoglycemic activity and acute oral toxicity of chromium methionine. complexes in mice[J]. Journal of Trace Elements in Medicine and Biology,2015(0):136-144.
APA Tang, H. Y.,Xiao, Q. G.,Xu, H. B.,&Zhang, Y..(2015).Hypoglycemic activity and acute oral toxicity of chromium methionine. complexes in mice.Journal of Trace Elements in Medicine and Biology(0),136-144.
MLA Tang, H. Y.,et al."Hypoglycemic activity and acute oral toxicity of chromium methionine. complexes in mice".Journal of Trace Elements in Medicine and Biology .0(2015):136-144.
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