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The principle of compromise in competition: exploring stability condition of protein folding
Alternative TitleSci. Bull.
Xu, J.; Han, M. Z.; Ren, Y.; Li, J. H.
2015
Source PublicationScience Bulletin
Issue1Pages:76-85
AbstractThermodynamic hypothesis and kinetic stability are currently used to understand protein folding. The former assumes that free energy minimum is the exclusive dominant mechanism in most cases, while the latter shows that some proteins have even lower free energy in intermediate states and their native states are kinetically trapped in the higher free energy region. This article explores the stability condition of protein structures on the basis of our study of complex chemical systems. We believe that separating one from another is not reasonable since they should be coupled, and protein structures should be dominated by at least two mechanisms resulting in different characteristic states. It is concluded that: (1) Structures of proteins are dynamic, showing multiple characteristic states emerging alternately and each dominated by a respective mechanism. (2) Compromise in competition of multiple dominant mechanisms might be the key to understanding the stability of protein structures. (3) The dynamic process of protein folding should be depicted through the time series of both its energetic and structural changes, which is much meaningful and applicable than the free energy landscape.
KeywordProtein Folding Dynamic Structure Multiple Mechanisms Compromise In Competition Mesoscale Stability Molecular-dynamics Simulations Complex-systems Transactivation Domain Multiscale Methodology Kix Domain Peptide Binding Energy Creb Flow
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Indexed BySCI
Language英语
WOS IDWOS:000347924400010
Citation statistics
Cited Times:6[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/11862
Collection研究所(批量导入)
Recommended Citation
GB/T 7714
Xu, J.,Han, M. Z.,Ren, Y.,et al. The principle of compromise in competition: exploring stability condition of protein folding[J]. Science Bulletin,2015(1):76-85.
APA Xu, J.,Han, M. Z.,Ren, Y.,&Li, J. H..(2015).The principle of compromise in competition: exploring stability condition of protein folding.Science Bulletin(1),76-85.
MLA Xu, J.,et al."The principle of compromise in competition: exploring stability condition of protein folding".Science Bulletin .1(2015):76-85.
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