CAS OpenIR  > 研究所(批量导入)
Tumor Necrosis Factor Receptor 2 (TNFR2)center dot Interleukin-17 Receptor D (IL-17RD) Heteromerization Reveals a Novel Mechanism for NF-kappa B Activation
Alternative TitleJ. Biol. Chem.
Yang, S. G.; Wang, Y. Y.; Mei, K. R.; Zhang, S.; Sun, X. J.; Ren, F. L.; Liu, S. H.; Yang, Z.; Wang, X. Q.; Qin, Z. H.; Chang, Z. J.
2015
Source PublicationJournal of Biological Chemistry
Issue2Pages:861-871
AbstractTNF receptor 2 (TNFR2) exerts diverse roles in the pathogenesis of inflammatory and autoimmune diseases. Here, we report that TNFR2 but not TNFR1 forms a heteromer with interleukin-17 receptor D (IL-17RD), also named Sef, to activate NF-kappa B signaling. TNFR2 associates with IL-17RD, leading to mutual receptor aggregation and TRAF2 recruitment, which further activate the downstream cascade of NF-kappa B signaling. Depletion of IL-17RD impaired TNFR2-mediated activation of NF-kappa B signaling. Importantly, IL-17RD was markedly increased in renal tubular epithelial cells in nephritis rats, and a strong interaction of TNFR2 and IL-17RD was observed in the renal epithelia. The IL-17RD center dot TNFR2 complex in activation of NF-kappa B may explain the role of TNFR2 in inflammatory diseases including nephritis.
KeywordTnf Receptor Ligand Cells Kinase Kidney Alpha Hsef Sef Localization Inflammation
URL查看原文
Indexed BySCI
Language英语
WOS IDWOS:000347778200016
Citation statistics
Cited Times:13[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/11873
Collection研究所(批量导入)
Recommended Citation
GB/T 7714
Yang, S. G.,Wang, Y. Y.,Mei, K. R.,et al. Tumor Necrosis Factor Receptor 2 (TNFR2)center dot Interleukin-17 Receptor D (IL-17RD) Heteromerization Reveals a Novel Mechanism for NF-kappa B Activation[J]. Journal of Biological Chemistry,2015(2):861-871.
APA Yang, S. G..,Wang, Y. Y..,Mei, K. R..,Zhang, S..,Sun, X. J..,...&Chang, Z. J..(2015).Tumor Necrosis Factor Receptor 2 (TNFR2)center dot Interleukin-17 Receptor D (IL-17RD) Heteromerization Reveals a Novel Mechanism for NF-kappa B Activation.Journal of Biological Chemistry(2),861-871.
MLA Yang, S. G.,et al."Tumor Necrosis Factor Receptor 2 (TNFR2)center dot Interleukin-17 Receptor D (IL-17RD) Heteromerization Reveals a Novel Mechanism for NF-kappa B Activation".Journal of Biological Chemistry .2(2015):861-871.
Files in This Item:
File Name/Size DocType Version Access License
Tumor Necrosis Facto(4186KB)期刊论文出版稿限制开放CC BY-NC-SAApplication Full Text
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Yang, S. G.]'s Articles
[Wang, Y. Y.]'s Articles
[Mei, K. R.]'s Articles
Baidu academic
Similar articles in Baidu academic
[Yang, S. G.]'s Articles
[Wang, Y. Y.]'s Articles
[Mei, K. R.]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Yang, S. G.]'s Articles
[Wang, Y. Y.]'s Articles
[Mei, K. R.]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.