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Enzyme-Responsive Release of Doxorubicin from Monodisperse Dipeptide-Based Nanocarriers for Highly Efficient Cancer Treatment In Vitro
Alternative TitleAdv. Funct. Mater.
Zhang, He1; Fei, Jinbo1; Yan, Xuehai2; Wang, Anhe3; Li, Junbai1
2015-02-25
Source PublicationADVANCED FUNCTIONAL MATERIALS
ISSN1616-301X
Volume25Issue:8Pages:1193-1204
Abstract

Small aldehyde molecule are demonstrated to induce cationic diphenylalanine to assemble into monodisperse enzyme-responsive nanocarriers with high biocompatibility and excellent biodegradability. The formation of Schiff base covalent bond and accompanying pi-pi interaction of aromatic rings are found to be the mainly driving forces for the assembly of the nanocarriers. Interestingly, the nanocarriers show autofluorescence due to the n-pi* transitions of C = N bonds, which lends them visually traceable property in living cells. Importantly, the nanocarriers can be taken in by cells and biodegraded in the cells. In addition, doxorubicin is easily loaded into the nanocarriers with high encapsulation amount, and its release can be triggered by tyrisin under physiological conditions. Noticeably, even at a very low drug concentration, the doxorubicin-loaded nanocarriers still exhibit a much higher killing capacity of HeLa cells in vitro, compared to the equivalent-dose free doxorubicin, indicating they have a great potential biomedical application.

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Small aldehyde molecule are demonstrated to induce cationic diphenylalanine to assemble into monodisperse enzyme-responsive nanocarriers with high biocompatibility and excellent biodegradability. The formation of Schiff base covalent bond and accompanying pi-pi interaction of aromatic rings are found to be the mainly driving forces for the assembly of the nanocarriers. Interestingly, the nanocarriers show autofluorescence due to the n-pi* transitions of C = N bonds, which lends them visually traceable property in living cells. Importantly, the nanocarriers can be taken in by cells and biodegraded in the cells. In addition, doxorubicin is easily loaded into the nanocarriers with high encapsulation amount, and its release can be triggered by tyrisin under physiological conditions. Noticeably, even at a very low drug concentration, the doxorubicin-loaded nanocarriers still exhibit a much higher killing capacity of HeLa cells in vitro, compared to the equivalent-dose free doxorubicin, indicating they have a great potential biomedical application.

KeywordDrug-delivery Systems Peptide Nanotubes Anticancer Drug Supramolecular Hydrogels Ph Temperature Nanowires Polysaccharide Resistance Micelles
SubtypeArticle
WOS HeadingsScience & Technology ; Physical Sciences ; Technology
DOI10.1002/adfm.201403119
URL查看原文
Indexed BySCI
Language英语
WOS KeywordDRUG-DELIVERY SYSTEMS ; PEPTIDE NANOTUBES ; ANTICANCER DRUG ; SUPRAMOLECULAR HYDROGELS ; PH ; TEMPERATURE ; NANOWIRES ; POLYSACCHARIDE ; RESISTANCE ; MICELLES
WOS Research AreaChemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
WOS SubjectChemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter
WOS IDWOS:000349817200003
Citation statistics
Cited Times:119[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/11889
Collection研究所(批量导入)
Affiliation1.Chinese Acad Sci, Inst Chem, Beijing Natl Lab Mol Sci, CAS Key Lab Colloid Interface & Chem Thermodynam, Beijing 100190, Peoples R China
2.Chinese Acad Sci, Inst Proc Engn, Natl Key Lab Biochem Engn, Beijing 100190, Peoples R China
3.Natl Ctr Nanosci & Technol, Beijing 100190, Peoples R China
Recommended Citation
GB/T 7714
Zhang, He,Fei, Jinbo,Yan, Xuehai,et al. Enzyme-Responsive Release of Doxorubicin from Monodisperse Dipeptide-Based Nanocarriers for Highly Efficient Cancer Treatment In Vitro[J]. ADVANCED FUNCTIONAL MATERIALS,2015,25(8):1193-1204.
APA Zhang, He,Fei, Jinbo,Yan, Xuehai,Wang, Anhe,&Li, Junbai.(2015).Enzyme-Responsive Release of Doxorubicin from Monodisperse Dipeptide-Based Nanocarriers for Highly Efficient Cancer Treatment In Vitro.ADVANCED FUNCTIONAL MATERIALS,25(8),1193-1204.
MLA Zhang, He,et al."Enzyme-Responsive Release of Doxorubicin from Monodisperse Dipeptide-Based Nanocarriers for Highly Efficient Cancer Treatment In Vitro".ADVANCED FUNCTIONAL MATERIALS 25.8(2015):1193-1204.
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