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Magnetic nanoparticles (MNPs) covalently coated by PEO-PPO-PEO block copolymer for drug delivery
Wang, Ning1; Guan, Yueping2; Yang, Liangrong1; Jia, Lianwei1; Wei, Xuetuan1; Liu, Huizhou1; Guo, Chen1
2013-04-01
Source PublicationJOURNAL OF COLLOID AND INTERFACE SCIENCE
ISSN0021-9797
Volume395Issue:0Pages:50-57
AbstractA stable drug carrier has been prepared by covalently coating magnetic nanoparticles (MNPs) with PEO-PPO-PEO block copolymer Pluronic P85. The particles were characterized by TEM, XRD, DLS, VSM, FTIR, and TGA. A typical product has a 15 nm magnetite core and a 100 nm hydrodynamic diameter with a narrow size distribution and is superparamagnetic with large saturation magnetization (57.102 emu/g) at room temperature. The covalently-coated Pluronic-MNPs (MagPluronics) were proven to be stable in different conditions, such as aqueous solution, 0.2 M PBS solution, and pH 13.5 solution, which would be significant for biological applications. Furthermore, MagPluronics also possess temperature-responsive property acquired from the Pluronic copolymer layer on their surface, which can cause conformational change of Pluronics and improve load and delivery efficiency of the particles. The temperature-controlled loading and releasing of hydrophobic model drug curcumin were tested with these particles. A loading efficiency of 81.3% and a sustained release of more than 4 days were achieved in simulated human body condition. It indicates that the covalently-coated MagPluronics are stable carriers with good drug-loading capacity and controlled-release property. (C) 2012 Elsevier Inc. All rights reserved.
KeywordMagnetic Nanoparticles Pluronic Stable Carrier Temperature-responsive Curcumin Drug Delivery System
SubtypeArticle
WOS HeadingsScience & Technology ; Physical Sciences
DOI10.1016/j.jcis.2012.11.062
Indexed BySCI
Language英语
WOS KeywordIRON-OXIDE NANOPARTICLES ; AQUEOUS-SOLUTIONS ; BIOMEDICAL APPLICATIONS ; H-1-NMR SPECTROSCOPY ; TARGETING DELIVERY ; IN-VITRO ; CURCUMIN ; ANTIBACTERIAL ; ENCAPSULATION ; CYTOTOXICITY
WOS Research AreaChemistry
WOS SubjectChemistry, Physical
WOS IDWOS:000315935800008
Citation statistics
Cited Times:52[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/13313
Collection研究所(批量导入)
Affiliation1.Chinese Acad Sci, Inst Proc Engn, Lab Separat Sci & Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China
2.Univ Sci & Technol Beijing, Sch Mat Sci & Engn, Beijing 100083, Peoples R China
Recommended Citation
GB/T 7714
Wang, Ning,Guan, Yueping,Yang, Liangrong,et al. Magnetic nanoparticles (MNPs) covalently coated by PEO-PPO-PEO block copolymer for drug delivery[J]. JOURNAL OF COLLOID AND INTERFACE SCIENCE,2013,395(0):50-57.
APA Wang, Ning.,Guan, Yueping.,Yang, Liangrong.,Jia, Lianwei.,Wei, Xuetuan.,...&Guo, Chen.(2013).Magnetic nanoparticles (MNPs) covalently coated by PEO-PPO-PEO block copolymer for drug delivery.JOURNAL OF COLLOID AND INTERFACE SCIENCE,395(0),50-57.
MLA Wang, Ning,et al."Magnetic nanoparticles (MNPs) covalently coated by PEO-PPO-PEO block copolymer for drug delivery".JOURNAL OF COLLOID AND INTERFACE SCIENCE 395.0(2013):50-57.
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