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Development of pneumococcal polysaccharide conjugate vaccine with long spacer arm
Wu, Dinglong1,2; Ji, Shaoyang1; Hu, Tao1
2013-11-19
Source PublicationVACCINE
ISSN0264-410X
Volume31Issue:48Pages:5623-5626
AbstractStreptococcus pneumoniae is a serious Gram-positive pathogen responsible for several life-threatening pneumococcal diseases. Pneumococcal capsular polysaccharide (CPS) is a key virulence determinant of S. pneumoniae and its immunogenicity can be improved by conjugation with a carrier protein. Reductive amination, the most widely used approach for pneumococcal CPS conjugate vaccine (PCV), suffers from low conjugation efficiency and the problem of steric hindrance. Here, copper-catalyzed azide-alkyne cycloaddition was used for development of PCV with long spacer arm (L-PCV). Tetanus toxoid (TT) was used as the carrier protein. The long spacer arm in L-PCV can minimize the problem of steric hindrance between CPS and IT, thereby improving the CPS-specific antibody titers in the mice model. L-PCV can also induce high avidity functional antibody and elicit immunological memory in response to the native CPS. (C) 2013 Elsevier Ltd. All rights reserved.
KeywordStreptococcus Pneumoniae Capsular Polysaccharide Conjugate Vaccine Azide-alkyne Cycloaddition
SubtypeArticle
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
DOI10.1016/j.vaccine.2013.09.065
Indexed BySCI
Language英语
WOS KeywordSTREPTOCOCCUS-PNEUMONIAE ; IMMUNOGENICITY ; EPITOPE ; ADULTS
WOS Research AreaImmunology ; Research & Experimental Medicine
WOS SubjectImmunology ; Medicine, Research & Experimental
WOS IDWOS:000327580300001
Citation statistics
Cited Times:4[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/13329
Collection研究所(批量导入)
Affiliation1.Chinese Acad Sci, Natl Key Lab Biochem Engn, Inst Proc Engn, Beijing 100190, Peoples R China
2.Fujian Agr & Forestry Univ, Coll Life Sci, Fuzhou 350002, Fujian Province, Peoples R China
Recommended Citation
GB/T 7714
Wu, Dinglong,Ji, Shaoyang,Hu, Tao. Development of pneumococcal polysaccharide conjugate vaccine with long spacer arm[J]. VACCINE,2013,31(48):5623-5626.
APA Wu, Dinglong,Ji, Shaoyang,&Hu, Tao.(2013).Development of pneumococcal polysaccharide conjugate vaccine with long spacer arm.VACCINE,31(48),5623-5626.
MLA Wu, Dinglong,et al."Development of pneumococcal polysaccharide conjugate vaccine with long spacer arm".VACCINE 31.48(2013):5623-5626.
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