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| Multifunctional polymer vesicles for ultrasensitive magnetic resonance imaging and drug delivery | |
| Ren, Tianbin2; Liu, Qiuming2; Lu, Hang2; Liu, Hongmei1,3; Zhang, Xin1; Du, Jianzhong2 | |
| 2012 | |
| Source Publication | JOURNAL OF MATERIALS CHEMISTRY
 |
| ISSN | 0959-9428 |
| Volume | 22Issue:24Pages:12329-12338 |
| Abstract | Presented in this article is the synthesis of a new class of block copolymer, poly(ethylene oxide)-block-poly(tert-butyl acrylate-stat-acrylic acid) [PEO-b-P(AA-stat-tBA)], which can self-assemble into polymer vesicles with tuneable sizes at various conditions. The biocompatible and hydrophilic PEO chains form the vesicle coronas, while the PAA-stat-PtBA chains form the membrane. Superparamagnetic iron oxide nanoparticles (SPIONs) were generated in situ within the membrane of the polymer vesicles by nanoprecipitation. H-1 NMR, GPC, DLS, TGA, VSM and TEM were employed to characterize the structure and properties of the block copolymer, polymer vesicles and Fe3O4-decorated magnetic polymer vesicles. The water-dispersible, biocompatible, drug deliverable and superparamagnetic polymer vesicles exhibited excellent colloidal stability at a range of pH conditions and very high T-2 relaxivity, demonstrating ultra-sensitivity for magnetic resonance imaging and promising potential applications in nanomedicine. |
| Keyword | Polymer Vesicles Ultrasensitive Magnetic Resonance Imaging Drug Delivery |
| Subtype | Article |
| WOS Headings | Science & Technology ; Physical Sciences ; Technology |
| DOI | 10.1039/c2jm31891a |
| Indexed By | SCI |
| Language | 英语 |
| WOS Keyword | IRON-OXIDE NANOPARTICLES ; CONTRAST AGENTS ; BLOCK-COPOLYMER ; DESIGN ; HOMOPOLYMERS ; MICELLES ; CANCER |
| WOS Research Area | Chemistry ; Materials Science |
| WOS Subject | Chemistry, Physical ; Materials Science, Multidisciplinary |
| WOS ID | WOS:000304561900064 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.ipe.ac.cn/handle/122111/13356 |
| Collection | 研究所（批量导入） |
| Affiliation | 1.Chinese Acad Sci, Inst Proc Engn, Natl Key Lab Biochem Engn, Beijing 100190, Peoples R China 2.Tongji Univ, Minist Educ, Key Lab Adv Civil Engn Mat, Sch Mat Sci & Engn,Res Ctr Adv Mat, Shanghai 201804, Peoples R China 3.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China |
| Recommended Citation GB/T 7714 | Ren, Tianbin,Liu, Qiuming,Lu, Hang,et al. Multifunctional polymer vesicles for ultrasensitive magnetic resonance imaging and drug delivery[J]. JOURNAL OF MATERIALS CHEMISTRY,2012,22(24):12329-12338. |
| APA | Ren, Tianbin,Liu, Qiuming,Lu, Hang,Liu, Hongmei,Zhang, Xin,&Du, Jianzhong.(2012).Multifunctional polymer vesicles for ultrasensitive magnetic resonance imaging and drug delivery.JOURNAL OF MATERIALS CHEMISTRY,22(24),12329-12338. |
| MLA | Ren, Tianbin,et al."Multifunctional polymer vesicles for ultrasensitive magnetic resonance imaging and drug delivery".JOURNAL OF MATERIALS CHEMISTRY 22.24(2012):12329-12338. |
| Files in This Item: | ||||||
| File Name/Size | DocType | Version | Access | License | ||
| Multifunctional poly（175KB） | 期刊论文 | 出版稿 | 限制开放 | Apache License | Application Full Text | |
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