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Multifunctional polymer vesicles for ultrasensitive magnetic resonance imaging and drug delivery
Ren, Tianbin2; Liu, Qiuming2; Lu, Hang2; Liu, Hongmei1,3; Zhang, Xin1; Du, Jianzhong2
2012
Source PublicationJOURNAL OF MATERIALS CHEMISTRY
ISSN0959-9428
Volume22Issue:24Pages:12329-12338
AbstractPresented in this article is the synthesis of a new class of block copolymer, poly(ethylene oxide)-block-poly(tert-butyl acrylate-stat-acrylic acid) [PEO-b-P(AA-stat-tBA)], which can self-assemble into polymer vesicles with tuneable sizes at various conditions. The biocompatible and hydrophilic PEO chains form the vesicle coronas, while the PAA-stat-PtBA chains form the membrane. Superparamagnetic iron oxide nanoparticles (SPIONs) were generated in situ within the membrane of the polymer vesicles by nanoprecipitation. H-1 NMR, GPC, DLS, TGA, VSM and TEM were employed to characterize the structure and properties of the block copolymer, polymer vesicles and Fe3O4-decorated magnetic polymer vesicles. The water-dispersible, biocompatible, drug deliverable and superparamagnetic polymer vesicles exhibited excellent colloidal stability at a range of pH conditions and very high T-2 relaxivity, demonstrating ultra-sensitivity for magnetic resonance imaging and promising potential applications in nanomedicine.
KeywordPolymer Vesicles Ultrasensitive Magnetic Resonance Imaging Drug Delivery
SubtypeArticle
WOS HeadingsScience & Technology ; Physical Sciences ; Technology
DOI10.1039/c2jm31891a
Indexed BySCI
Language英语
WOS KeywordIRON-OXIDE NANOPARTICLES ; CONTRAST AGENTS ; BLOCK-COPOLYMER ; DESIGN ; HOMOPOLYMERS ; MICELLES ; CANCER
WOS Research AreaChemistry ; Materials Science
WOS SubjectChemistry, Physical ; Materials Science, Multidisciplinary
WOS IDWOS:000304561900064
Citation statistics
Cited Times:71[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/13356
Collection研究所(批量导入)
Affiliation1.Chinese Acad Sci, Inst Proc Engn, Natl Key Lab Biochem Engn, Beijing 100190, Peoples R China
2.Tongji Univ, Minist Educ, Key Lab Adv Civil Engn Mat, Sch Mat Sci & Engn,Res Ctr Adv Mat, Shanghai 201804, Peoples R China
3.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Ren, Tianbin,Liu, Qiuming,Lu, Hang,et al. Multifunctional polymer vesicles for ultrasensitive magnetic resonance imaging and drug delivery[J]. JOURNAL OF MATERIALS CHEMISTRY,2012,22(24):12329-12338.
APA Ren, Tianbin,Liu, Qiuming,Lu, Hang,Liu, Hongmei,Zhang, Xin,&Du, Jianzhong.(2012).Multifunctional polymer vesicles for ultrasensitive magnetic resonance imaging and drug delivery.JOURNAL OF MATERIALS CHEMISTRY,22(24),12329-12338.
MLA Ren, Tianbin,et al."Multifunctional polymer vesicles for ultrasensitive magnetic resonance imaging and drug delivery".JOURNAL OF MATERIALS CHEMISTRY 22.24(2012):12329-12338.
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