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Circulating Precursor CCR7(lo)PD-1(hi) CXCR5(+) CD4(+) T Cells Indicate Tfh Cell Activity and Promote Antibody Responses upon Antigen Reexposure
He, Jing1; Tsai, Louis M.2; Leong, Yew Ann2; Hu, Xin2,3; Ma, Cindy S.4,5; Chevalier, Nina4,5,6; Sun, Xiaolin1; Vandenberg, Kirsten7; Rockman, Steve7; Ding, Yan1; Zhu, Lei1; Wei, Wei8; Wang, Changqi9; Karnowski, Alexander10; Belz, Gabrielle T.10; Ghali, Joanna R.11; Cook, Matthew C.3,12; Riminton, D. Sean13; Veillette, Andre14; Schwartzberg, Pamela L.15; Mackay, Fabienne16; Brink, Robert4,5; Tangye, Stuart G.4,5; Vinuesa, Carola G.3; Mackay, Charles R.2; Li, Zhanguo1; Yu, Di2
2013-10-17
Source PublicationIMMUNITY
ISSN1074-7613
Volume39Issue:4Pages:770-781
AbstractFollicular B helper T (Tfh) cells support high affinity and long-term antibody responses. Here we found that within circulating CXCR5(+) CD4(+) T cells in humans and mice, the CCR7(lo)PD-1(hi) subset has a partial Tfh effector phenotype, whereas CCR7(hi) PD-1(lo) cells have a resting phenotype. The circulating CCR7(lo)PD-1(hi) subset was indicative of active Tfh differentiation in lymphoid organs and correlated with clinical indices in autoimmune diseases. Thus the CCR7(lo)PD-1(hi) subset provides a biomarker to monitor protective antibody responses during infection or vaccination and pathogenic antibody responses in autoimmune diseases. Differentiation of both CCR7(hi)PD-1(lo) and CCR7(lo)PD-1(hi) subsets required ICOS and BCL6, but not SAP, suggesting that circulating CXCR5(+) helper T cells are primarily generated before germinal centers. Upon antigen reencounter, CCR7(lo)PD-1(hi) CXCR5(+) precursors rapidly differentiate into mature Tfh cells to promote anti-body responses. Therefore, circulating CCR7(lo)PD-1(hi) CXCR5(+) CD4(+) T cells are generated during active Tfh differentiation and represent a new mechanism of immunological early memory.
SubtypeArticle
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
DOI10.1016/j.immuni.2013.09.007
Indexed BySCI
Language英语
WOS KeywordFOLLICULAR HELPER-CELL ; CENTER B-CELL ; CXC CHEMOKINE RECEPTOR-5 ; SYSTEMIC AUTOIMMUNITY ; BCL6 EXPRESSION ; CENTRAL MEMORY ; HIV-INFECTION ; EFFECTOR ; DIFFERENTIATION ; GENERATION
WOS Research AreaImmunology
WOS SubjectImmunology
WOS IDWOS:000330950000017
Citation statistics
Cited Times:298[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/13373
Collection研究所(批量导入)
Affiliation1.Peking Univ, Peoples Hosp, Dept Rheumatol & Immunol, Beijing 100044, Peoples R China
2.Monash Univ, Sch Biomed Sci, Mol Immunomodulat Lab, Clayton, Vic 3800, Australia
3.Australian Natl Univ, John Curtin Sch Med Res, Canberra, ACT 2601, Australia
4.Garvan Inst Med Res, Program Immunol, Darlinghurst, NSW 2010, Australia
5.Univ New S Wales, St Vincents Clin Sch, Darlinghurst, NSW 2010, Australia
6.Univ Med Ctr Freiburg, Dept Rheumatol & Clin Immunol, D-79106 Freiburg, Germany
7.BioCSL, Influenza Res & Dev, Parkville, Vic 3052, Australia
8.Chinese Acad Sci, Inst Proc Engn, Natl Key Lab Biochem Engn, Beijing 100190, Peoples R China
9.Shandong Acad Sci, Shandong Anal & Test Ctr, Lab Immunol Environm & Hlth, Jinan 250014, Shandong, Peoples R China
10.Walter & Eliza Hall Inst Med Res, Div Mol Immunol, Parkville, Vic 3052, Australia
11.Monash Univ, Ctr Inflammatory Dis, Clayton, Vic 3800, Australia
12.Australian Natl Univ, Sch Med, Canberra, ACT 2601, Australia
13.Concord Hosp, Dept Immunol, Concord, NSW 2139, Australia
14.Clin Res Inst Montreal, Montreal, PQ H2W 1R7, Canada
15.NHGRI, Bethesda, MD 20892 USA
16.Monash Univ, Dept Immunol, Clayton, Vic 3800, Australia
Recommended Citation
GB/T 7714
He, Jing,Tsai, Louis M.,Leong, Yew Ann,et al. Circulating Precursor CCR7(lo)PD-1(hi) CXCR5(+) CD4(+) T Cells Indicate Tfh Cell Activity and Promote Antibody Responses upon Antigen Reexposure[J]. IMMUNITY,2013,39(4):770-781.
APA He, Jing.,Tsai, Louis M..,Leong, Yew Ann.,Hu, Xin.,Ma, Cindy S..,...&Yu, Di.(2013).Circulating Precursor CCR7(lo)PD-1(hi) CXCR5(+) CD4(+) T Cells Indicate Tfh Cell Activity and Promote Antibody Responses upon Antigen Reexposure.IMMUNITY,39(4),770-781.
MLA He, Jing,et al."Circulating Precursor CCR7(lo)PD-1(hi) CXCR5(+) CD4(+) T Cells Indicate Tfh Cell Activity and Promote Antibody Responses upon Antigen Reexposure".IMMUNITY 39.4(2013):770-781.
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