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Neutralizing Antibodies Induced by Recombinant Virus-Like Particles of Enterovirus 71 Genotype C4 Inhibit Infection at Pre- and Post-attachment Steps
Ku, Zhiqiang1; Ye, Xiaohua1; Huang, Xulin1; Cai, Yicun1; Liu, Qingwei1; Li, Yan2; Su, Zhiguo2; Huang, Zhong1
2013-02-22
Source PublicationPLOS ONE
Volume8Issue:2Pages:57601
AbstractBackground: Enterovirus 71 (EV71) is a major causative agent of hand, foot and mouth disease, which has been prevalent in Asia-Pacific regions, causing significant morbidity and mortality in young children. Antibodies elicited by experimental EV71 vaccines could neutralize infection in vitro and passively protect animal models from lethal challenge, indicating that neutralizing antibodies play an essential role in protection. However, how neutralizing antibodies inhibit infection in vitro remains unclear.
SubtypeArticle
WOS HeadingsScience & Technology
Indexed BySCI
Language英语
WOS KeywordMOUTH-DISEASE ; VP1 PROTEIN ; MICE ; HAND ; IMMUNIZATION ; VACCINE ; LETHAL ; IDENTIFICATION ; CHALLENGE ; OUTBREAK
WOS Research AreaScience & Technology - Other Topics
WOS SubjectMultidisciplinary Sciences
WOS IDWOS:000316658800113
Citation statistics
Cited Times:52[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/13383
Collection研究所(批量导入)
Affiliation1.Chinese Acad Sci, Key Lab Mol Virol & Immunol, Inst Pasteur Shanghai, Shanghai Inst Biol Sci, Shanghai, Peoples R China
2.Chinese Acad Sci, Natl Key Lab Biochem Engn, Inst Proc Engn, Beijing, Peoples R China
Recommended Citation
GB/T 7714
Ku, Zhiqiang,Ye, Xiaohua,Huang, Xulin,et al. Neutralizing Antibodies Induced by Recombinant Virus-Like Particles of Enterovirus 71 Genotype C4 Inhibit Infection at Pre- and Post-attachment Steps[J]. PLOS ONE,2013,8(2):57601.
APA Ku, Zhiqiang.,Ye, Xiaohua.,Huang, Xulin.,Cai, Yicun.,Liu, Qingwei.,...&Huang, Zhong.(2013).Neutralizing Antibodies Induced by Recombinant Virus-Like Particles of Enterovirus 71 Genotype C4 Inhibit Infection at Pre- and Post-attachment Steps.PLOS ONE,8(2),57601.
MLA Ku, Zhiqiang,et al."Neutralizing Antibodies Induced by Recombinant Virus-Like Particles of Enterovirus 71 Genotype C4 Inhibit Infection at Pre- and Post-attachment Steps".PLOS ONE 8.2(2013):57601.
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