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Molecular structure matters: PEG-b-PLA nanoparticles with hydrophilicity and deformability demonstrate their advantages for high-performance delivery of anti-cancer drugs
Yue, Zhanguo1,2; You, Zuoxiang1,3; Yang, Qinzheng3; Lv, Piping1,2; Yue, Hua1; Wang, Bin1; Ni, Dezhi1,2; Su, Zhiguo1; Wei, Wei1; Ma, Guanghui1
2013
Source PublicationJOURNAL OF MATERIALS CHEMISTRY B
ISSN2050-750X
Volume1Issue:26Pages:3239-3247
AbstractVarious carriers are being advanced for anti-cancer therapy, which can protect drugs and ferry them to the target site. However, little understanding exists regarding the effect of molecular structure on anti-cancer drug delivery efficiency. To fill this knowledge gap, we take poly(lactic acid) (PLA), poly(lactide-co-glycolide) (PLGA), and poly-ethylene glycol-co-poly-lactide (PEG-b-PLA) polymers as prototype materials and comparatively explore the inherent relationship between the molecular structure and the delivery ability. Compared with PLA and PLGA NPs, PEG-b-PLA ones possess the advantages of longer blood circulation time, more tumor accumulation, and better intratumoral delivery ability. Subsequent mechanism investigations reveal that the molecular structure will regulate the polymer arrangement and render NPs different hydrophilicity/deformability, which dictate the distinct delivery performances. Finally, the superior PEG-b-PLA NPs are further loaded with the anti-cancer drug paclitaxel (PTX) and functionalized with magnetic (M) Fe3O4 nanocrystals. As-designed PTX/M PEG-b-PLA NPs show much better tumor inhibition efficacy and fewer side effects than the commercialized Taxol (R) formulation, strongly supporting their use as high-performance carriers for anti-cancer therapy.
SubtypeArticle
WOS HeadingsScience & Technology ; Technology
DOI10.1039/c3tb20406e
Indexed BySCI
Language英语
WOS KeywordMEMBRANE EMULSIFICATION ; CANCER ; MICROSPHERES ; MACROPHAGES
WOS Research AreaMaterials Science
WOS SubjectMaterials Science, Biomaterials
WOS IDWOS:000320272000001
Citation statistics
Cited Times:23[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/13406
Collection研究所(批量导入)
Affiliation1.Chinese Acad Sci, Inst Proc Engn, Natl Key Lab Biochem Engn, Beijing 100190, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Shandong Polytech Univ, Dept Food & Bioengn, Jinan 250353, Shandong, Peoples R China
Recommended Citation
GB/T 7714
Yue, Zhanguo,You, Zuoxiang,Yang, Qinzheng,et al. Molecular structure matters: PEG-b-PLA nanoparticles with hydrophilicity and deformability demonstrate their advantages for high-performance delivery of anti-cancer drugs[J]. JOURNAL OF MATERIALS CHEMISTRY B,2013,1(26):3239-3247.
APA Yue, Zhanguo.,You, Zuoxiang.,Yang, Qinzheng.,Lv, Piping.,Yue, Hua.,...&Ma, Guanghui.(2013).Molecular structure matters: PEG-b-PLA nanoparticles with hydrophilicity and deformability demonstrate their advantages for high-performance delivery of anti-cancer drugs.JOURNAL OF MATERIALS CHEMISTRY B,1(26),3239-3247.
MLA Yue, Zhanguo,et al."Molecular structure matters: PEG-b-PLA nanoparticles with hydrophilicity and deformability demonstrate their advantages for high-performance delivery of anti-cancer drugs".JOURNAL OF MATERIALS CHEMISTRY B 1.26(2013):3239-3247.
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