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Development of an efficient CFD-simulation method to optimize the structure parameters of an airlift sonobioreactor
Liu, Rui; Liu, Ying; Liu, Chun-Zhao
2013-02-01
Source PublicationCHEMICAL ENGINEERING RESEARCH & DESIGN
Volume91Issue:2Pages:211-220
AbstractA two-dimensional CFD model was developed for optimizing the structure design of an airlift sonobioreactor for hairy root culture, and a height to diameter ratio of 4 was found suitable for hairy root culture because both oxygen interphase mass transfer rate and liquid flow rate were high in the whole culture process. The installation position of ultrasound transducers was optimized with the help of CFD simulation, the ultrasound transducers set at three layers around the bioreactor wall gave the highest TKE value, turbulent dissipation rate and liquid flow rate among all installation positions tested, which is positive for the dissolved oxygen mass transfer into the center of hairy root clumps. The optimized structure of the airlift sonobioreactor provided great mass transfer performance and sharply reduced the gradient of dissolved oxygen in root domain. The detection results of dissolved oxygen concentration in hairy root clumps before and after ultrasound stimulation proved that ultrasound could enhance the mass transfer of dissolved oxygen into root clumps, which is an advantage for hairy root growth and secondary metabolite accumulation. (c) 2012 The Institution of Chemical Engineers. Published by Elsevier B.V. All rights reserved.
KeywordComputational Fluid Dynamics Reactor Design Hydrodynamics Sonobioreactor Hairy Root
SubtypeArticle
WOS HeadingsScience & Technology ; Technology
Indexed BySCI
Language英语
WOS KeywordHAIRY-ROOT CULTURES ; BUBBLE-COLUMN REACTORS ; CELL-SUSPENSION-CULTURES ; MASS-TRANSFER BEHAVIOR ; LOW-ENERGY ULTRASOUND ; FLUID-DYNAMICS ; OXYGEN REQUIREMENTS ; ARTEMISIA-ANNUA ; SINGLE-PHASE ; BIOREACTOR
WOS Research AreaEngineering
WOS SubjectEngineering, Chemical
WOS IDWOS:000315614000003
Citation statistics
Cited Times:10[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/13437
Collection研究所(批量导入)
AffiliationChinese Acad Sci, Inst Proc Engn, Natl Key Lab Biochem Engn, Beijing 100190, Peoples R China
Recommended Citation
GB/T 7714
Liu, Rui,Liu, Ying,Liu, Chun-Zhao. Development of an efficient CFD-simulation method to optimize the structure parameters of an airlift sonobioreactor[J]. CHEMICAL ENGINEERING RESEARCH & DESIGN,2013,91(2):211-220.
APA Liu, Rui,Liu, Ying,&Liu, Chun-Zhao.(2013).Development of an efficient CFD-simulation method to optimize the structure parameters of an airlift sonobioreactor.CHEMICAL ENGINEERING RESEARCH & DESIGN,91(2),211-220.
MLA Liu, Rui,et al."Development of an efficient CFD-simulation method to optimize the structure parameters of an airlift sonobioreactor".CHEMICAL ENGINEERING RESEARCH & DESIGN 91.2(2013):211-220.
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