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Codelivery of mTERT siRNA and paclitaxel by chitosan-based nanoparticles promoted synergistic tumor suppression
Wei, Wei1; Lv, Pi-Ping1,2; Chen, Xiao-Ming1,2; Yue, Zhan-Guo1,2; Fu, Qiang1,3; Liu, Shi-Ying1,2; Yue, Hua1; Ma, Guang-Hui1
2013-05-01
Source PublicationBIOMATERIALS
Volume34Issue:15Pages:3912-3923
AbstractClinical applications of siRNA are being hindered by poor intracellular uptake and enzymatic degradation. To address these problems, we devised an oral delivery system for telomerase reverse transcriptase siRNA using N-((2-hydroxy-3-trimethylammonium) propyl) chitosan chloride (HTCC) nanoparticles (HNP). Both the porous structure and the positive charge of HNP facilitated siRNA encapsulation. The outer coating of HTCC not only protected siRNA from enzymatic degradation, but also improved siRNA permeability in intestine tract. In vivo and in vitro experiments proved that HNP could effectively deliver siRNA to lesion site and further into tumor cells. On the basis of confirming the antitumor activity of HNP:siRNA, we continued to encapsulate a hydrophobic chemotherapeutic drug-paclitaxel (PTX) into HNP to form a "two-in-one" nano-complex (HNP:siRNA/PTX). We demonstrated that HNP:siRNA/PTX could simultaneously ferry siRNA and PTX into tumor cells and increase drug concentration, which, in particular, was much more effective in tumor suppression than that of traditional cocktail therapy. These results suggested that the HNP, as a powerful delivery system for both siRNA and chemotherapeutic drug, would have a far-reaching application in human cancer therapy. (C) 2013 Elsevier Ltd. All rights reserved.
KeywordSirna Paclitaxel Drug Delivery Chitosan Nanoparticles
SubtypeArticle
WOS HeadingsScience & Technology ; Technology
Indexed BySCI
Language英语
WOS KeywordCANCER-CELLS ; CO-DELIVERY ; QUATERNIZED CHITOSAN ; TELOMERASE ACTIVITY ; IN-VIVO ; GROWTH ; THERAPEUTICS ; THERAPY ; SYSTEM ; TARGET
WOS Research AreaEngineering ; Materials Science
WOS SubjectEngineering, Biomedical ; Materials Science, Biomaterials
WOS IDWOS:000317168700018
Citation statistics
Cited Times:98[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/13438
Collection研究所(批量导入)
Affiliation1.Chinese Acad Sci, Inst Proc Engn, Natl Key Lab Biochem Engn, Beijing 100190, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Shandong Univ, Life Sci Coll, Key Lab Cell & Dev Biol, Jinan 250100, Peoples R China
Recommended Citation
GB/T 7714
Wei, Wei,Lv, Pi-Ping,Chen, Xiao-Ming,et al. Codelivery of mTERT siRNA and paclitaxel by chitosan-based nanoparticles promoted synergistic tumor suppression[J]. BIOMATERIALS,2013,34(15):3912-3923.
APA Wei, Wei.,Lv, Pi-Ping.,Chen, Xiao-Ming.,Yue, Zhan-Guo.,Fu, Qiang.,...&Ma, Guang-Hui.(2013).Codelivery of mTERT siRNA and paclitaxel by chitosan-based nanoparticles promoted synergistic tumor suppression.BIOMATERIALS,34(15),3912-3923.
MLA Wei, Wei,et al."Codelivery of mTERT siRNA and paclitaxel by chitosan-based nanoparticles promoted synergistic tumor suppression".BIOMATERIALS 34.15(2013):3912-3923.
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