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Engineering Biomaterial-Associated Complement Activation to Improve Vaccine Efficacy
Liu, Yuan1,2; Yin, Ying3; Wang, Lianyan1; Zhang, Weifeng1,2; Chen, Xiaoming1,2; Yang, Xiaoxiao1; Xu, Junjie3; Ma, Guanghui1
2013-09-01
Source PublicationBIOMACROMOLECULES
Volume14Issue:9Pages:3321-3328
AbstractThe complement system plays an important role in innate and adaptive immunity, which suggests that complement activation could be exploited as a potential strategy for vaccine adjuvants. Here we explored the potential of chitosan-based microparticles (CS-NH2 MPs) as a vaccine adjuvant with an active surface for complement activation due to the abundance of amino groups. In vaccination studies, using recombinant anthrax protective antigen as a model antigen, compared with the control microparticles (amino-cross-linked MPs), we found that microparticles (MPs) with abundant amino groups significantly enhanced higher antigen-specific IgG titers in vivo and enhanced the production of IL-4 and IFN-gamma with ex vivo restimulation. Furthermore, proliferative responses of splenocytes to ex vivo antigen restimulation were enhanced following immunization with MPs with amino groups. Overall, these results indicated that CS-NH2 MPs with a high surface density of amino groups were favorable for complement activation and immune responses. Our data provide further design principles for studies on complement-activating MPs as a vaccine platform.
SubtypeArticle
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine ; Physical Sciences
Indexed BySCI
Language英语
WOS KeywordT-CELL IMMUNITY ; INNATE IMMUNITY ; IN-VIVO ; CHITOSAN ; NANOPARTICLES ; ADJUVANTS ; DELIVERY ; SURFACES ; SYSTEM ; MODEL
WOS Research AreaBiochemistry & Molecular Biology ; Chemistry ; Polymer Science
WOS SubjectBiochemistry & Molecular Biology ; Chemistry, Organic ; Polymer Science
WOS IDWOS:000330095500041
Citation statistics
Cited Times:31[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/13486
Collection研究所(批量导入)
Affiliation1.Chinese Acad Sci, Inst Proc Engn, PLA Key Lab Biopharmaceut Prod & Formulat Engn, Natl Key Lab Biochem Engn, Beijing 100190, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Beijing Inst Biotechnol, Lab Vaccine & Antibody Engn, Beijing 100071, Peoples R China
Recommended Citation
GB/T 7714
Liu, Yuan,Yin, Ying,Wang, Lianyan,et al. Engineering Biomaterial-Associated Complement Activation to Improve Vaccine Efficacy[J]. BIOMACROMOLECULES,2013,14(9):3321-3328.
APA Liu, Yuan.,Yin, Ying.,Wang, Lianyan.,Zhang, Weifeng.,Chen, Xiaoming.,...&Ma, Guanghui.(2013).Engineering Biomaterial-Associated Complement Activation to Improve Vaccine Efficacy.BIOMACROMOLECULES,14(9),3321-3328.
MLA Liu, Yuan,et al."Engineering Biomaterial-Associated Complement Activation to Improve Vaccine Efficacy".BIOMACROMOLECULES 14.9(2013):3321-3328.
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