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Hairy Root Culture: Bioreactor Design and Process Intensification
Stiles, Amanda R.; Liu, Chun-Zhao; Doran, PM
2013
Source PublicationBIOTECHNOLOGY OF HAIRY ROOT SYSTEMS
Volume134Issue:0Pages:91-114
AbstractThe cultivation of hairy roots for the production of secondary metabolites offers numerous advantages; hairy roots have a fast growth rate, are genetically stable, and are relatively simple to maintain in phytohormone free media. Hairy roots provide a continuous source of secondary metabolites, and are useful for the production of chemicals for pharmaceuticals, cosmetics, and food additives. In order for hairy roots to be utilized on a commercial scale, it is necessary to scale-up their production. Over the last several decades, significant research has been conducted on the cultivation of hairy roots in various types of bioreactor systems. In this review, we discuss the advantages and disadvantages of various bioreactor systems, the major factors related to large-scale bioreactor cultures, process intensification technologies and overview the mathematical models and computer-aided methods that have been utilized for bioreactor design and development.
KeywordBioreactor Computational Fluid Dynamics Hairy Roots Process Intensification
SubtypeArticle
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
Indexed BySCI
Language英语
WOS KeywordARTEMISIA-ANNUA L ; NUTRIENT SPRINKLE BIOREACTOR ; TROPANE ALKALOID PRODUCTION ; BUBBLE-COLUMN REACTORS ; MASS-TRANSFER BEHAVIOR ; IN-VITRO PRODUCTION ; PLANT-CELL CULTURE ; FLUID-DYNAMICS ; HYOSCYAMUS-MUTICUS ; PANAX-GINSENG
WOS Research AreaBiotechnology & Applied Microbiology ; Microbiology
WOS SubjectBiotechnology & Applied Microbiology ; Microbiology
WOS IDWOS:000331550700005
Citation statistics
Cited Times:13[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/13506
Collection研究所(批量导入)
AffiliationChinese Acad Sci, Inst Proc Engn, Natl Key Lab Biochem Engn, Beijing 100190, Peoples R China
Recommended Citation
GB/T 7714
Stiles, Amanda R.,Liu, Chun-Zhao,Doran, PM. Hairy Root Culture: Bioreactor Design and Process Intensification[J]. BIOTECHNOLOGY OF HAIRY ROOT SYSTEMS,2013,134(0):91-114.
APA Stiles, Amanda R.,Liu, Chun-Zhao,&Doran, PM.(2013).Hairy Root Culture: Bioreactor Design and Process Intensification.BIOTECHNOLOGY OF HAIRY ROOT SYSTEMS,134(0),91-114.
MLA Stiles, Amanda R.,et al."Hairy Root Culture: Bioreactor Design and Process Intensification".BIOTECHNOLOGY OF HAIRY ROOT SYSTEMS 134.0(2013):91-114.
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