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Optimization of Reaction Parameters for the Synthesis of Chromium Methionine Complex Using Response Surface Methodology
Tang, Hai-yan1,2,3; Xiao, Qing-gui1,2; Xu, Hong-bin1,2; Zhang, Yi1,2
2013-04-01
Source PublicationORGANIC PROCESS RESEARCH & DEVELOPMENT
Volume17Issue:4Pages:632-640
AbstractThis study deals with a new and better protocol to prepare chromium methionine using aqueous ethanol solution as the reaction medium. Response surface methodology (RSM) coupled with Box-Behnken design was employed to model and optimize the operational parameters of this protocol. The ethanol content of aqueous ethanol, the molar ratio of methionine and Cr(III), reaction temperature, and reaction time were chosen as independent variables, and their combined effects on the conversion of Cr(III) (response 1) and the yield of chromium methionine (response 2) were investigated. The optimal values of the parameters were found to be the following: ethanol content of aqueous ethanol is 48.5%; n(Met)/n(NaOH)/n(CrCl3 center dot 6H(2)O) = 4.31:4.31:1; reaction time is 127 min; reaction temperature is 81.1 degrees C; initial Cr(III) concentration is 0.25 mol/L. The conversion of Cr(III) and the yield of chromium methionine are up to 99.79% and 99.23%, respectively, under the optimal conditions. The analysis of variance (ANOVA) and regression with R-2 values of 0.9984 for the conversion of Cr(III) and 0.9974 for the yield of chromium methionine illustrate that the experimental results are in good agreement with the predicted values, and the models can be used to predict the synthesis of chromium methionine successfully.
SubtypeArticle
WOS HeadingsScience & Technology ; Physical Sciences
Indexed BySCI
Language英语
WOS KeywordIN-VIVO ; SUPPLEMENT ; DESIGN ; PICOLINATE ; DNA
WOS Research AreaChemistry
WOS SubjectChemistry, Applied ; Chemistry, Organic
WOS IDWOS:000318001500002
Citation statistics
Cited Times:18[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/13507
Collection研究所(批量导入)
Affiliation1.Inst Proc Engn, Natl Engn Lab Hydromet Cleaner Prod Technol, Beijing 100190, Peoples R China
2.Chinese Acad Sci, Key Lab Green Proc & Engn, Beijing 100190, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100190, Peoples R China
Recommended Citation
GB/T 7714
Tang, Hai-yan,Xiao, Qing-gui,Xu, Hong-bin,et al. Optimization of Reaction Parameters for the Synthesis of Chromium Methionine Complex Using Response Surface Methodology[J]. ORGANIC PROCESS RESEARCH & DEVELOPMENT,2013,17(4):632-640.
APA Tang, Hai-yan,Xiao, Qing-gui,Xu, Hong-bin,&Zhang, Yi.(2013).Optimization of Reaction Parameters for the Synthesis of Chromium Methionine Complex Using Response Surface Methodology.ORGANIC PROCESS RESEARCH & DEVELOPMENT,17(4),632-640.
MLA Tang, Hai-yan,et al."Optimization of Reaction Parameters for the Synthesis of Chromium Methionine Complex Using Response Surface Methodology".ORGANIC PROCESS RESEARCH & DEVELOPMENT 17.4(2013):632-640.
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