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Microspheres and Microcapsules for Protein Delivery: Strategies of Drug Activity Retention
Wang, Lianyan1; Liu, Yuan1,2; Zhang, Weifeng1,2; Chen, Xiaoming1,2; Yang, Tingyuan1; Ma, Guanghui1
2013-10-01
Source PublicationCURRENT PHARMACEUTICAL DESIGN
Volume19Issue:35Pages:6340-6352
AbstractWith the recent progress in biotechnology and genetic engineering, a variety of proteins have formed a very important class of therapeutic agents. However, most proteins have short half-lives in vivo requiring multiple treatments to provide efficacy. In order to overcome this limitation, sustained release systems as hydrophilic microspheres and hydrophobic microcapsules have received extensive attention in recent years. As therapeutic proteins delivery systems, it is necessary to maintain protein bioactivity during microspheres or microcapsules formation as much as possible. This paper reviews different influencing factors that are closely involved in protein denaturation during the preparation of hydrophilic polymer microspheres and hydrophobic polymer microcapsules. The various strategies usually employed for overcoming these obstacles are described in detail. Both processing and formulation parameters can be modified for improving protein stability. The maximum or full protein stability retention within the microspheres or microcapsules might be achieved by individual or combined optimized strategies. In addition, the common techniques for proteins stability determination are also briefly reviewed.
KeywordHydrophilic Polymer Microspheres Hydrophobic Polymer Microcapsules Protein Delivery Activity Retention Strategies
SubtypeArticle
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
Indexed BySCI
Language英语
WOS KeywordHUMAN GROWTH-HORMONE ; ALPHA-CHYMOTRYPSIN STABILITY ; POLY-DL-LACTIDE-POLY(ETHYLENE GLYCOL) MICROSPHERES ; SUSTAINED-RELEASE FORMULATION ; POLYMERIC MULTILAYER CAPSULES ; PLGA MICROSPHERES ; CHITOSAN MICROSPHERES ; BIODEGRADABLE MICROSPHERES ; POLY(ETHYLENE GLYCOL) ; IN-VITRO
WOS Research AreaPharmacology & Pharmacy
WOS SubjectPharmacology & Pharmacy
WOS IDWOS:000324629400010
Citation statistics
Cited Times:24[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/13549
Collection研究所(批量导入)
Affiliation1.Chinese Acad Sci, Inst Proc Engn, Natl Key Lab Biochem Engn, Beijing 100190, Peoples R China
2.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Wang, Lianyan,Liu, Yuan,Zhang, Weifeng,et al. Microspheres and Microcapsules for Protein Delivery: Strategies of Drug Activity Retention[J]. CURRENT PHARMACEUTICAL DESIGN,2013,19(35):6340-6352.
APA Wang, Lianyan,Liu, Yuan,Zhang, Weifeng,Chen, Xiaoming,Yang, Tingyuan,&Ma, Guanghui.(2013).Microspheres and Microcapsules for Protein Delivery: Strategies of Drug Activity Retention.CURRENT PHARMACEUTICAL DESIGN,19(35),6340-6352.
MLA Wang, Lianyan,et al."Microspheres and Microcapsules for Protein Delivery: Strategies of Drug Activity Retention".CURRENT PHARMACEUTICAL DESIGN 19.35(2013):6340-6352.
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