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Bio-inspired protein-gold nanoconstruct with core-void-shell structure: beyond a chemo drug carrier
Liu, Xiangyou1,6; Wei, Wei2; Huang, Shijiao3,4; Lin, Shrong-Shi1; Zhang, Xin5; Zhang, Chuanmao3,4; Du, Yuguang6; Ma, Guanghui2; Li, Mei7; Mann, Stephen7; Ma, Ding1
2013
Source PublicationJOURNAL OF MATERIALS CHEMISTRY B
Volume1Issue:25Pages:3136-3143
AbstractChemotherapy has been widely used in clinical practice for cancer treatment. A major challenge for a successful chemotherapy is to potentiate the anticancer activity, whilst reducing the severe side effects. In this context, we design a bio-inspired protein-gold nanoconstruct (denoted as AFt-Au hereafter) with a core-void-shell structure which exhibits a high selectivity towards carcinoma cells. Anticancer drug 5-fluorouracil (5-FU) can be sequestered into the void space of the construct to produce an integrated nanoscale hybrid AFt-AuFU that exhibits an increased cellular uptake of 5-FU. More importantly, AFt-Au, serving as a bio-nano-chemosensitizer, renders carcinoma cells more susceptible to 5-FU by cell-cycle regulation, and thus, leads to a dramatic decrease of the IC50 value (i.e. the drug concentration required to kill 50% of the cell population) of 5-FU in HepG2 cells from 138.3 mu M to 9.2 mu M. Besides HepG2 cells, a remarkably enhanced anticancer efficacy and potentially reduced side effects are also achieved in other cell lines. Our further work reveals that the drug 5-FU is internalized into cells with AFt-Au primarily via receptor-mediated endocytosis (RME). After internalization, AFt-AuFU colocalizes with lysosomes which trigger the release of 5-FU under acidic conditions. Overall, our approach provides a novel procedure in nanoscience that promises an optimal chemotherapeutic outcome.
SubtypeArticle
WOS HeadingsScience & Technology ; Technology
Indexed BySCI
Language英语
WOS KeywordHORSE SPLEEN APOFERRITIN ; CANCER-CELLS ; FERRITIN RECEPTORS ; ANTICANCER DRUGS ; PHASE-TRANSITION ; CELLULAR UPTAKE ; IRON RELEASE ; CYCLIN-E ; NANOPARTICLES ; 5-FLUOROURACIL
WOS Research AreaMaterials Science
WOS SubjectMaterials Science, Biomaterials
WOS IDWOS:000319965800002
Citation statistics
Cited Times:17[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/13602
Collection研究所(批量导入)
Affiliation1.Peking Univ, Beijing Natl Lab Mol Sci, Coll Chem & Mol Engn, Beijing 100871, Peoples R China
2.Chinese Acad Sci, Inst Proc Engn, Natl Key Lab Biochem Engn, Beijing 100190, Peoples R China
3.Peking Univ, MOE Key Lab Cell Proliferat & Differentiat, Coll Life Sci, Beijing 100871, Peoples R China
4.Peking Univ, State Key Lab Biomembrane & Membrane Biotechnol, Coll Life Sci, Beijing 100871, Peoples R China
5.Scripps Res Inst, Dept Mol & Expt Med, La Jolla, CA 92037 USA
6.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China
7.Univ Bristol, Sch Chem, Ctr Organized Matter Chem, Bristol BS6 1TS, Avon, England
Recommended Citation
GB/T 7714
Liu, Xiangyou,Wei, Wei,Huang, Shijiao,et al. Bio-inspired protein-gold nanoconstruct with core-void-shell structure: beyond a chemo drug carrier[J]. JOURNAL OF MATERIALS CHEMISTRY B,2013,1(25):3136-3143.
APA Liu, Xiangyou.,Wei, Wei.,Huang, Shijiao.,Lin, Shrong-Shi.,Zhang, Xin.,...&Ma, Ding.(2013).Bio-inspired protein-gold nanoconstruct with core-void-shell structure: beyond a chemo drug carrier.JOURNAL OF MATERIALS CHEMISTRY B,1(25),3136-3143.
MLA Liu, Xiangyou,et al."Bio-inspired protein-gold nanoconstruct with core-void-shell structure: beyond a chemo drug carrier".JOURNAL OF MATERIALS CHEMISTRY B 1.25(2013):3136-3143.
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