Knowledge Management System Of Institute of process engineering,CAS
| Nanoparticles-based multi-adjuvant whole cell tumor vaccine for cancer immunotherapy | |
| Liu, Shi-Ying1,2; Wei, Wei1; Yue, Hua1; Ni, De-Zhi1,2; Yue, Zhan-Guo1,2; Wang, Shuang1,2; Fu, Qiang1,3; Wang, Yue-Qi1,2; Ma, Guang-Hui1; Su, Zhi-Guo1 | |
| 2013-11-01 | |
| Source Publication | BIOMATERIALS
 |
| Volume | 34Issue:33Pages:8291-8300 |
| Abstract | Whole cell tumor vaccine (WCTV), as a potential treatment modality, elicits limited immune responses because of the poor immunogenicity. To address this issue, researchers have attempted to transduce a cytokine adjuvant into tumor cells, but these single-adjuvant WCTVs curtail the high expectations. In present study, we constructed a multi-adjuvant WCTV based on the nanopartides modified with cell penetrating peptide, which could facilitate the transportation of granulocyte macrophage colony-stimulating factor (GM-CSF) and interleukin 2 (IL-2) into tumor cells. After inactivation, as-designed multi-adjuvant WCTV exhibited programmed promotions on DC recruitment, antigen presentation, and T-cell activation. In vivo evaluations demonstrated the satisfactory effects on tumor growth suppression, metastasis inhibition, and recurrence prevention. Therefore, the nanoparticles-based multiadjuvant WCTV may serve as a high-performance treatment for anti-tumor immunotherapy. (C) 2013 Elsevier Ltd. All rights reserved. |
| Keyword | Whole Cell Tumor Vaccine Adjuvant Nanoparticle Cytokine |
| Subtype | Article |
| WOS Headings | Science & Technology ; Technology |
| Indexed By | SCI |
| Language | 英语 |
| WOS Keyword | DENDRITIC CELLS ; CROSS-PRESENTATION ; CHEMOTHERAPY ; IMMUNITY ; MELANOMA ; TAT |
| WOS Research Area | Engineering ; Materials Science |
| WOS Subject | Engineering, Biomedical ; Materials Science, Biomaterials |
| WOS ID | WOS:000324720700028 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.ipe.ac.cn/handle/122111/13624 |
| Collection | 研究所（批量导入） |
| Affiliation | 1.Chinese Acad Sci, Inst Proc Engn, Natl Key Lab Biochem Engn, Beijing 100190, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Shandong Univ, Key Lab Cell & Dev Biol, Life Sci Coll, Jinan 250100, Peoples R China |
| Recommended Citation GB/T 7714 | Liu, Shi-Ying,Wei, Wei,Yue, Hua,et al. Nanoparticles-based multi-adjuvant whole cell tumor vaccine for cancer immunotherapy[J]. BIOMATERIALS,2013,34(33):8291-8300. |
| APA | Liu, Shi-Ying.,Wei, Wei.,Yue, Hua.,Ni, De-Zhi.,Yue, Zhan-Guo.,...&Su, Zhi-Guo.(2013).Nanoparticles-based multi-adjuvant whole cell tumor vaccine for cancer immunotherapy.BIOMATERIALS,34(33),8291-8300. |
| MLA | Liu, Shi-Ying,et al."Nanoparticles-based multi-adjuvant whole cell tumor vaccine for cancer immunotherapy".BIOMATERIALS 34.33(2013):8291-8300. |
| Files in This Item: | ||||||
| File Name/Size | DocType | Version | Access | License | ||
| Nanoparticles-based （1925KB） | 期刊论文 | 出版稿 | 限制开放 | CC BY-NC-SA | Application Full Text | |
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