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Nanoparticles-based multi-adjuvant whole cell tumor vaccine for cancer immunotherapy
Liu, Shi-Ying1,2; Wei, Wei1; Yue, Hua1; Ni, De-Zhi1,2; Yue, Zhan-Guo1,2; Wang, Shuang1,2; Fu, Qiang1,3; Wang, Yue-Qi1,2; Ma, Guang-Hui1; Su, Zhi-Guo1
Source PublicationBIOMATERIALS
AbstractWhole cell tumor vaccine (WCTV), as a potential treatment modality, elicits limited immune responses because of the poor immunogenicity. To address this issue, researchers have attempted to transduce a cytokine adjuvant into tumor cells, but these single-adjuvant WCTVs curtail the high expectations. In present study, we constructed a multi-adjuvant WCTV based on the nanopartides modified with cell penetrating peptide, which could facilitate the transportation of granulocyte macrophage colony-stimulating factor (GM-CSF) and interleukin 2 (IL-2) into tumor cells. After inactivation, as-designed multi-adjuvant WCTV exhibited programmed promotions on DC recruitment, antigen presentation, and T-cell activation. In vivo evaluations demonstrated the satisfactory effects on tumor growth suppression, metastasis inhibition, and recurrence prevention. Therefore, the nanoparticles-based multiadjuvant WCTV may serve as a high-performance treatment for anti-tumor immunotherapy. (C) 2013 Elsevier Ltd. All rights reserved.
KeywordWhole Cell Tumor Vaccine Adjuvant Nanoparticle Cytokine
WOS HeadingsScience & Technology ; Technology
Indexed BySCI
WOS Research AreaEngineering ; Materials Science
WOS SubjectEngineering, Biomedical ; Materials Science, Biomaterials
WOS IDWOS:000324720700028
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Document Type期刊论文
Affiliation1.Chinese Acad Sci, Inst Proc Engn, Natl Key Lab Biochem Engn, Beijing 100190, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Shandong Univ, Key Lab Cell & Dev Biol, Life Sci Coll, Jinan 250100, Peoples R China
Recommended Citation
GB/T 7714
Liu, Shi-Ying,Wei, Wei,Yue, Hua,et al. Nanoparticles-based multi-adjuvant whole cell tumor vaccine for cancer immunotherapy[J]. BIOMATERIALS,2013,34(33):8291-8300.
APA Liu, Shi-Ying.,Wei, Wei.,Yue, Hua.,Ni, De-Zhi.,Yue, Zhan-Guo.,...&Su, Zhi-Guo.(2013).Nanoparticles-based multi-adjuvant whole cell tumor vaccine for cancer immunotherapy.BIOMATERIALS,34(33),8291-8300.
MLA Liu, Shi-Ying,et al."Nanoparticles-based multi-adjuvant whole cell tumor vaccine for cancer immunotherapy".BIOMATERIALS 34.33(2013):8291-8300.
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