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The Advance of Gene Delivery Vectors
Li Yan1,2; Yang Jun1; Liu Gui-Ying3; Zhang Xin1
2013-10-01
Source PublicationPROGRESS IN BIOCHEMISTRY AND BIOPHYSICS
Volume40Issue:10Pages:998-1007
AbstractGene therapy has rapidly emerged as a promising method for the treatment of numerous diseases. However, the intrinsic deficiencies of gene-based drugs, such as enzymatic degradation in the body, poor membrane penetrability and lack of target ability, have limited the development of its therapeutic application. Herein, it is important for efficient gene therapy to develop efficient and safe gene vectors that can deliver the gene-based drugs to targeted cells. This paper reviews the current development in gene delivery vectors, especially summarizes the characteristic and development of viral vectors, non-viral vectors and nanoparticles with tracing ability.
KeywordGene Therapy Viral Vectors Liposomes Polymers Dendrimers
SubtypeArticle
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
Indexed BySCI
Language英语
WOS KeywordPOLY-L-LYSINE ; SMALL INTERFERING RNA ; MARROW STROMAL CELLS ; SIRNA DELIVERY ; IN-VIVO ; NONVIRAL VECTORS ; LIPID NANOPARTICLES ; POLYETHYLENE-GLYCOL ; CATIONIC LIPOSOMES ; SYSTEMIC DELIVERY
WOS Research AreaBiochemistry & Molecular Biology ; Biophysics
WOS SubjectBiochemistry & Molecular Biology ; Biophysics
WOS IDWOS:000326312500013
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/13678
Collection研究所(批量导入)
Affiliation1.Chinese Acad Sci, Inst Proc Engn, Natl Key Lab Biochem Engn, Beijing 100190, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Capital Med Univ, Dept Pediat, Affiliated Beijing Anzhen Hosp, Beijing 100029, Peoples R China
Recommended Citation
GB/T 7714
Li Yan,Yang Jun,Liu Gui-Ying,et al. The Advance of Gene Delivery Vectors[J]. PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS,2013,40(10):998-1007.
APA Li Yan,Yang Jun,Liu Gui-Ying,&Zhang Xin.(2013).The Advance of Gene Delivery Vectors.PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS,40(10),998-1007.
MLA Li Yan,et al."The Advance of Gene Delivery Vectors".PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS 40.10(2013):998-1007.
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基因治疗药物输递系统的研究现状及发展趋势(881KB)期刊论文出版稿限制开放CC BY-NC-SAApplication Full Text
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