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Polymer hydrophobicity regulates paclitaxel distribution in microspheres, release profile and cytotoxicity in vitro
Wang, Lianyan1; Cai, Mingming1,2; Liu, Yuan1,3; Yang, Tingyuan1; Zeng, Yejing1; Zhang, Yueling1; Li, Qiang1; Zhu, Baocheng2; Ma, Guanghui1
2015-05-01
Source PublicationPOWDER TECHNOLOGY
ISSN0032-5910
Volume275Issue:MAYPages:77-84
Abstract

Water-insoluble drugs such as paclitaxel (PTX) face a huge challenge for clinical applications due to their low aqueous solubility. In this study, uniform-sized poly (DL-lactic acid) (PLA), poly(DL-lactic-co-glycolic acid) (PLGA) and poly( ethylene glycol-co-lactide add) (PELA) microspheres containing PTX were prepared by premix membrane emulsification technique integrated with solvent evaporation method. The different hydrophobicity of polymer led to different distribution and crystal morphology of PTX in microspheres, which further resulted in different loading and encapsulation efficiency, release profile in vitro and cytotoxicity. The PLGA microspheres showed the highest loading and encapsulation efficiency of PTX (5.15%, 70.46%), followed by PLA microspheres (4.33%, 6433%), together with PELA microspheres (3.35%, 56.68%). The results of PTX release profile in vitro suggested that PLGA and PELA microspheres achieved a more rapid release rate than PLA microspheres due to their hydrophilic property. The antitumor activity in vitro was also evaluated by Lewis Lung Cells (LLC). The PTX-PLGA microspheres exhibited excellent antitumor activity compared with PLA and PELA microspheres, even much better than Taxol. Therefore, the PLGA microspheres show great potential in application as delivery carriers for water-insoluble drugs, PTX and others. (C) 2015 Elsevier B.V. All rights reserved.

KeywordHydrophobicity Paclitaxel Polymer Microspheres Distribution Crystal Morphology Antitumor Activity
SubtypeArticle
Subject AreaEngineering
WOS HeadingsScience & Technology ; Technology
DOI10.1016/j.powtec.2015.01.041
Indexed BySCI
Language英语
WOS KeywordMembrane Emulsification Technique ; Solvent Evaporation Method ; Pla Microcapsules ; Size Distribution ; Nanoparticles ; Delivery ; Drug ; Encapsulation ; Cancer ; Formulation
Funding Project973 Program [2009CB903300] ; National Natural Science Foundation of China [50703043] ; Chinese Academy of Sciences [KJCX2-YW-M02]
WOS Research AreaEngineering
WOS SubjectEngineering, Chemical
WOS IDWOS:000351801300009
Citation statistics
Cited Times:15[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/13775
Collection研究所(批量导入)
Corresponding AuthorWang, Lianyan
Affiliation1.Chinese Acad Sci, Inst Proc Engn, Natl Key Lab Biochem Engn, Beijing 100190, Peoples R China
2.Agr Univ Hebei, Coll Life Sci, Baoding 071001, Hebei, Peoples R China
3.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Wang, Lianyan,Cai, Mingming,Liu, Yuan,et al. Polymer hydrophobicity regulates paclitaxel distribution in microspheres, release profile and cytotoxicity in vitro[J]. POWDER TECHNOLOGY,2015,275(MAY):77-84.
APA Wang, Lianyan.,Cai, Mingming.,Liu, Yuan.,Yang, Tingyuan.,Zeng, Yejing.,...&Ma, Guanghui.(2015).Polymer hydrophobicity regulates paclitaxel distribution in microspheres, release profile and cytotoxicity in vitro.POWDER TECHNOLOGY,275(MAY),77-84.
MLA Wang, Lianyan,et al."Polymer hydrophobicity regulates paclitaxel distribution in microspheres, release profile and cytotoxicity in vitro".POWDER TECHNOLOGY 275.MAY(2015):77-84.
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