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Conjugation of beta-glucan markedly increase the immunogencity of meningococcal group Y polysaccharide conjugate vaccine
Qiao, Weilin1,2; Ji, Shaoyang2; Zhao, Yubao1; Hu, Tao2
2015-04-21
Source PublicationVACCINE
ISSN0264-410X
Volume33Issue:17Pages:2066-2072
Abstract

Meningococcal disease is a fatal illness of sudden onset caused by Neisseria meningitides. Meningococcal capsular polysaccharide (CPS) is a major virulence factor that generally does not induce immunological memory. Conjugation with a carrier protein can significantly increase the immunogenicity of CPS and induce immunological memory. However, it is highly desired to optimize the CPS-specific immunogenicity of the conjugate vaccine. Although adjuvant has been widely used to improve the immunogenicity of antigens, co-administration and conjugation of adjuvant with the conjugate vaccine has rarely been investigated. As a stimulator of humoral and cellular immunity, beta-glucan can activate macrophages and trigger intracellular processes to secrete cytokines initiating inflammatory reactions. In the present study, a conjugate vaccine (CPS-TT) was generated by conjugation of tetanus toxoid (TT) with meningococcal group Y CPS. CPS-TT was further conjugated with beta-glucan to generate CPS-TT-G. Immunization with CPS-TT-G led to an 8.2-fold increase in the CPS-specific IgG titers as compared with CPS-TT. Presumably, conjugation of beta-glucan ensured the two components to simultaneously reach the antigen presenting cells and stimulate the immune response. In contrast, co-administration of beta-glucan suppressed the CPS-specific immunogenicity of CPS-TT. Thus, conjugation of beta-glucan is an effective strategy to markedly improve the CPS-specific immunogenicity of the conjugate vaccine. (C) 2015 Elsevier Ltd. All rights reserved.

KeywordMeningococcal Polysaccharide Conjugate Vaccine Beta-glucan Adjuvant
SubtypeArticle
Subject AreaImmunology ; Research & Experimental Medicine
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
DOI10.1016/j.vaccine.2015.02.045
Indexed BySCI
Language英语
WOS KeywordNeisseria-meningitidis ; Spacer Arm ; Group-a ; Disease ; Antigen ; Acid ; Immunization ; Protection ; Antibodies ; Serogroups
Funding ProjectBeijing Natural Science Foundation [7142104] ; National Natural Science Foundation of China [20906095, 11405199, 81402861] ; Science and Technology Service Network Initiative Project of Chinese Academy of Sciences [KFJ-EW-STS-027, KFJ-EW-STS-098]
WOS Research AreaImmunology ; Research & Experimental Medicine
WOS SubjectImmunology ; Medicine, Research & Experimental
WOS IDWOS:000353079100011
Citation statistics
Cited Times:7[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/13777
Collection研究所(批量导入)
Corresponding AuthorZhao, Yubao
Affiliation1.Univ South China, Sch Chem & Chem Engn, Hengyang 421001, Hunan, Peoples R China
2.Chinese Acad Sci, Inst Proc Engn, Natl Key Lab Biochem Engn, Beijing 100190, Peoples R China
Recommended Citation
GB/T 7714
Qiao, Weilin,Ji, Shaoyang,Zhao, Yubao,et al. Conjugation of beta-glucan markedly increase the immunogencity of meningococcal group Y polysaccharide conjugate vaccine[J]. VACCINE,2015,33(17):2066-2072.
APA Qiao, Weilin,Ji, Shaoyang,Zhao, Yubao,&Hu, Tao.(2015).Conjugation of beta-glucan markedly increase the immunogencity of meningococcal group Y polysaccharide conjugate vaccine.VACCINE,33(17),2066-2072.
MLA Qiao, Weilin,et al."Conjugation of beta-glucan markedly increase the immunogencity of meningococcal group Y polysaccharide conjugate vaccine".VACCINE 33.17(2015):2066-2072.
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