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Surface-Engineered Graphene Navigate Divergent Biological Outcomes toward Macrophages
Luo, Nana1,2; Ni, Dezhi1,2; Yue, Hua1; Wei, Wei1; Ma, Guanghui1,3

The "nano-bio" interface profoundly shapes the interaction between cells and nanomaterials and can even decide a cell's fate. As a nascent two-dimensional material, graphene has many unique attributes and is proposed to be a promising candidate for biomedical applications. Thus, for graphene-based applications, it is necessary to clarify how the graphene surface navigates biological outcomes when encountering "janitorial" cells (macrophages). For this purpose, we synthesized nanographene oxide (nGO) and engineered the surface with polyethylene glycol (PEG), bovine serum albumin (BSA), and poly(ether imide) (PEI). In contrast to pristine nGO, decoration with PEG and BSA hindered endocytosis and improved their benignancy toward macrophages. Contrarily, nGO-PEI commenced with favorable endocytosis but then suffered stagnation due to compromised macrophage viability. To unravel the underlying mechanisms regulating these diverse macrophage fates, we built a stepwise analysis. Compared to the others, nGO-PEI tended to interact electrostatically with mitochondria after their cellular internalization. Such an unexpected encounter disrupted the normal potential and integrity of mitochondria and then elicited an alteration in reactive oxygen species and cytochrome c. These responses further initiated the activation of the caspase family and ultimately dictated cells to undergo apoptosis. The advances described above will complement our knowledge of graphene functionality and serve to guide its application in biotechnological applications.

KeywordGraphene Oxide Macrophage Surface Engineering Biological Outcomes Apoptosis
Subject AreaScience & Technology - Other Topics ; Materials Science
WOS HeadingsScience & Technology ; Technology
Indexed BySCI
WOS KeywordWalled Carbon Nanotubes ; Nano-graphene ; Nanoparticle Size ; Drug-delivery ; Cell-death ; Oxide ; Nanomaterials ; Chemistry ; Apoptosis ; Proteins
Funding ProjectNational Basic Research Program of China (973 Program) [2013CB531505] ; National Nature Science Foundation of China [81302704] ; Beijing Nova Program [Z141102001814066]
WOS Research AreaScience & Technology - Other Topics ; Materials Science
WOS SubjectNanoscience & Nanotechnology ; Materials Science, Multidisciplinary
WOS IDWOS:000350614600026
Citation statistics
Cited Times:26[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Corresponding AuthorWei, Wei
Affiliation1.Chinese Acad Sci, Nat Key Lab Biochem Engn, Inst Proc Engn, Beijing 100190, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Collaborat Innovat Ctr Chem Sci & Engn, Tianjin 300072, Peoples R China
Recommended Citation
GB/T 7714
Luo, Nana,Ni, Dezhi,Yue, Hua,et al. Surface-Engineered Graphene Navigate Divergent Biological Outcomes toward Macrophages[J]. ACS APPLIED MATERIALS & INTERFACES,2015,7(9):5239-5247.
APA Luo, Nana,Ni, Dezhi,Yue, Hua,Wei, Wei,&Ma, Guanghui.(2015).Surface-Engineered Graphene Navigate Divergent Biological Outcomes toward Macrophages.ACS APPLIED MATERIALS & INTERFACES,7(9),5239-5247.
MLA Luo, Nana,et al."Surface-Engineered Graphene Navigate Divergent Biological Outcomes toward Macrophages".ACS APPLIED MATERIALS & INTERFACES 7.9(2015):5239-5247.
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