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Development of hypoxia-triggered prodrug micelles as doxorubicin carriers for tumor therapy
Liu, Hongmei2,3; Zhang, Ruilong2,4; Niu, Yunwei1; Li, Yan2,3; Qiao, Chenmeng5; Weng, Jie5; Li, Jun6; Zhang, Xiaoning6; Xiao, Zuobing1; Zhang, Xin1,2
2015
Source PublicationRSC ADVANCES
ISSN2046-2069
Volume5Issue:27Pages:20848-20857
Abstract

Hypoxia has a major role in tumor development and resistance to therapy. Therefore, the effective targeting and killing of hypoxic tumor cells is a key to successful tumor control. Here, we report the hypoxia-responsive prodrug micelles to deliver hydrophobic anticancer drug, which can selectively release the drugs to treat hypoxic tumor cells in a combined way. For this purpose, an azobenzene (AZO) bond, which imparts hypoxia sensitivity and specificity as cross linker, conjugated PEG-hexanethiol (PEG-C6) with combretastatin A-4 (CA4) to form PEG-C6-AZO-CA4 amphiphilicmolecule. These PEG-C6-AZO-CA4 molecules self-assemble into micelles, which can encapsulate hydrophobic anticancer drug. The drug release behavior from PEG-C6-AZO-CA4 micelles was studied under normoxic or hypoxic conditions and the combinations of CA4 with hydrophobic drugs for tumor treatment in vitro were also investigated. As the first example of using AZO linkages to develop anticancer prodrug micelles as hydrophobic anticancer drugs delivery to kill the hypoxic tumor cells in a combination way, this study establishes PEG-C6-AZO-CA4 micelles as a promising drug delivery platform for hypoxic tumor therapy.

KeywordCombretastatin A-4 Cancer-treatment Activatable Prodrug Fluorescent-probe Targeting Hypoxia Delivery Cells Acid Nanoparticles Absorption
SubtypeArticle
Subject AreaChemistry
WOS HeadingsScience & Technology ; Physical Sciences
DOI10.1039/c4ra14875d
Indexed BySCI
Language英语
WOS KeywordCombretastatin A-4 ; Cancer-treatment ; Activatable Prodrug ; Fluorescent-probe ; Targeting Hypoxia ; Delivery ; Cells ; Acid ; Nanoparticles ; Absorption
Funding ProjectNational Natural Science Foundation of China [21304099, 51203162, 51103159, 51373177] ; National High Technology Research and Development Program [2014AA020708, 2012AA022703, 2012AA020804] ; Instrument Developing Project of the Chinese Academy of Sciences [YZ201253, YZ201313] ; Open Funding Project of the National Key Laboratory of Biochemical Engineering [Y22504A169]
WOS Research AreaChemistry
WOS SubjectChemistry, Multidisciplinary
WOS IDWOS:000350221600030
Citation statistics
Cited Times:26[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/13846
Collection研究所(批量导入)
Corresponding AuthorXiao, Zuobing
Affiliation1.Shanghai Inst Technol, Sch Perfume & Aroma Technol, Shanghai 200233, Peoples R China
2.Chinese Acad Sci, Inst Proc Engn, Natl Key Lab Biochem Engn, Beijing 100190, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
4.Ocean Univ China, Inst Mat Sci & Engn, Qingdao 266100, Shandong, Peoples R China
5.Southwest Jiaotong Univ, Key Lab Adv Technol Mat, Sch Mat Sci & Engn, Chengdu 610031, Sichuan, Peoples R China
6.Tsinghua Univ, Sch Med, Collaborat Innovat Ctr Biotherapy, Beijing 100084, Peoples R China
Recommended Citation
GB/T 7714
Liu, Hongmei,Zhang, Ruilong,Niu, Yunwei,et al. Development of hypoxia-triggered prodrug micelles as doxorubicin carriers for tumor therapy[J]. RSC ADVANCES,2015,5(27):20848-20857.
APA Liu, Hongmei.,Zhang, Ruilong.,Niu, Yunwei.,Li, Yan.,Qiao, Chenmeng.,...&Zhang, Xin.(2015).Development of hypoxia-triggered prodrug micelles as doxorubicin carriers for tumor therapy.RSC ADVANCES,5(27),20848-20857.
MLA Liu, Hongmei,et al."Development of hypoxia-triggered prodrug micelles as doxorubicin carriers for tumor therapy".RSC ADVANCES 5.27(2015):20848-20857.
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