CAS OpenIR  > 生化工程国家重点实验室
Zwitterionic Poly(carboxybetaine)-based Cationic Liposomes for Effective Delivery of Small Interfering RNA Therapeutics without Accelerated Blood Clearance Phenomenon
Li, Yan1,2; Liu, Ruiyuan1,3; Shi, Yuanjie4; Zhang, Zhenzhong3; Zhang, Xin1
2015
Source PublicationTHERANOSTICS
ISSN1838-7640
Volume5Issue:6Pages:583-596
AbstractFor efficient delivery of small interfering RNA (siRNA) to the target diseased site in vivo, it is important to design suitable vehicles to control the blood circulation of siRNA. It has been shown that surface modification of cationic liposome/siRNA complexes (lipoplexes) with polyethylene glycol (PEG) could enhance the circulation time of lipoplexes. However, the first injection of PEGylated lipoplexes in vivo induces accelerated blood clearance and enhances hepatic accumulation of the following injected PEGylated lipoplexes, which is known as the accelerated blood clearance (ABC) phenomenon. Herein, we developed zwitterionic poly(carboxybetaine) (PCB) modified lipoplexes for the delivery of siRNA therapeutics, which could avoid protein adsorption and enhance the stability of lipoplexes as that for PEG. Quite different from the PEGylation, the PCBylated lipoplexes could avoid ABC phenomenon, which extended the blood circulation time and enhanced the tumor accumulation of lipoplexes in vivo. After accumulation in tumor site, the PCBylation could promote the cellular uptake and endosomal/lysosomal escape of lipoplexes due to its unique chemical structure and pH-sensitive ability. With excellent tumor accumulation, cellular uptake and endosomal/lysosomal escape abilities, the PCBylated lipoplexes significantly inhibited tumor growth and induced tumor cell apoptosis.
KeywordCationic Liposomes Sirna Therapeutics Poly(Carboxybetaine) Polyethylene Glycol Accelerated Blood Clearance (Abc) Phenomenon
SubtypeArticle
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
DOI10.7150/thno.11234
Indexed BySCI
Language英语
WOS KeywordPEGYLATED LIPOSOMES ; REPEATED INJECTION ; SYSTEMIC DELIVERY ; GENE DELIVERY ; POLYETHYLENE-GLYCOL ; PLA-NANOPARTICLES ; ENDOSOMAL ESCAPE ; NUCLEIC-ACID ; SIRNA ; EFFICIENCY
WOS Research AreaResearch & Experimental Medicine
WOS SubjectMedicine, Research & Experimental
WOS IDWOS:000353064200003
Citation statistics
Cited Times:42[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/16740
Collection生化工程国家重点实验室
Affiliation1.Chinese Acad Sci, Inst Proc Engn, Natl Key Lab Biochem Engn, Beijing 100190, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Zhengzhou Univ, Sch Pharmaceut Sci, Zhengzhou 450001, Peoples R China
4.Univ Beijing Inst Technol, Sch Life Sci, Beijing 100081, Peoples R China
Recommended Citation
GB/T 7714
Li, Yan,Liu, Ruiyuan,Shi, Yuanjie,et al. Zwitterionic Poly(carboxybetaine)-based Cationic Liposomes for Effective Delivery of Small Interfering RNA Therapeutics without Accelerated Blood Clearance Phenomenon[J]. THERANOSTICS,2015,5(6):583-596.
APA Li, Yan,Liu, Ruiyuan,Shi, Yuanjie,Zhang, Zhenzhong,&Zhang, Xin.(2015).Zwitterionic Poly(carboxybetaine)-based Cationic Liposomes for Effective Delivery of Small Interfering RNA Therapeutics without Accelerated Blood Clearance Phenomenon.THERANOSTICS,5(6),583-596.
MLA Li, Yan,et al."Zwitterionic Poly(carboxybetaine)-based Cationic Liposomes for Effective Delivery of Small Interfering RNA Therapeutics without Accelerated Blood Clearance Phenomenon".THERANOSTICS 5.6(2015):583-596.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Li, Yan]'s Articles
[Liu, Ruiyuan]'s Articles
[Shi, Yuanjie]'s Articles
Baidu academic
Similar articles in Baidu academic
[Li, Yan]'s Articles
[Liu, Ruiyuan]'s Articles
[Shi, Yuanjie]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Li, Yan]'s Articles
[Liu, Ruiyuan]'s Articles
[Shi, Yuanjie]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.